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Page 1
Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma.
Welsh SJ, Barwick BG, Meermeier EW, Riggs DL, Shi CX, Zhu YX, Sharik ME, Du MT, Abrego Rocha LD, Garbitt VM, Stein CK, Petit JL, Meurice N, Tafoya Alvarado Y, Fonseca R, Todd KT, Brown S, Hammond ZJ, Cuc NH, Wittenberg C, Herzog C, Roschke AV, Demchenko YN, Chen WD, Li P, Liao W, Leonard WJ, Lonial S, Bahlis NJ, Neri P, Boise LH, Chesi M, Bergsagel PL. Welsh SJ, et al. Among authors: stein ck. Blood Cancer Discov. 2024 Jan 8;5(1):34-55. doi: 10.1158/2643-3230.BCD-23-0062. Blood Cancer Discov. 2024. PMID: 37767768 Free PMC article.
Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control.
Pawlyn C, Bright MD, Buros AF, Stein CK, Walters Z, Aronson LI, Mirabella F, Jones JR, Kaiser MF, Walker BA, Jackson GH, Clarke PA, Bergsagel PL, Workman P, Chesi M, Morgan GJ, Davies FE. Pawlyn C, et al. Among authors: stein ck. Blood Cancer J. 2017 Mar 31;7(3):e549. doi: 10.1038/bcj.2017.27. Blood Cancer J. 2017. PMID: 28362441 Free PMC article.
MYC dysregulation in the progression of multiple myeloma.
Misund K, Keane N, Stein CK, Asmann YW, Day G, Welsh S, Van Wier SA, Riggs DL, Ahmann G, Chesi M, Viswanatha DS, Kumar SK, Dispenzieri A, Gonzalez-Calle V, Kyle RA, O'Dwyer M, Rajkumar SV, Kortüm KM, Keats JJ; MMRF CoMMpass Network; Fonseca R, Stewart AK, Kuehl WM, Braggio E, Bergsagel PL. Misund K, et al. Among authors: stein ck. Leukemia. 2020 Jan;34(1):322-326. doi: 10.1038/s41375-019-0543-4. Epub 2019 Aug 22. Leukemia. 2020. PMID: 31439946 Free PMC article. No abstract available.
Identification of PIKfyve kinase as a target in multiple myeloma.
de Campos CB, Zhu YX, Sepetov N, Romanov S, Bruins LA, Shi CX, Stein CK, Petit JL, Polito AN, Sharik ME, Meermeier EW, Ahmann GJ, Armenta IDL, Kruse J, Bergsagel PL, Chesi M, Meurice N, Braggio E, Stewart AK. de Campos CB, et al. Among authors: stein ck. Haematologica. 2020 Jun;105(6):1641-1649. doi: 10.3324/haematol.2019.222729. Epub 2019 Oct 3. Haematologica. 2020. PMID: 31582538 Free PMC article.
Tumor burden limits bispecific antibody efficacy through T cell exhaustion averted by concurrent cytotoxic therapy.
Meermeier EW, Welsh SJ, Sharik ME, Du MT, Garbitt VM, Riggs DL, Shi CX, Stein CK, Bergsagel M, Chau B, Wheeler ML, Bezman N, Wang F, Strop P, Bergsagel PL, Chesi M. Meermeier EW, et al. Among authors: stein ck. Blood Cancer Discov. 2021 Jul;2(4):354-369. doi: 10.1158/2643-3230.BCD-21-0038. Blood Cancer Discov. 2021. PMID: 34258584 Free PMC article.
The Vk*MYC Mouse Model recapitulates human multiple myeloma evolution and genomic diversity.
Maura F, Coffey DG, Stein CK, Braggio E, Ziccheddu B, Sharik ME, Du M, Alvarado YT, Shi CX, Zhu YX, Meermeier EW, Morgan GJ, Landgren O, Leif Bergsagel P, Chesi M. Maura F, et al. Among authors: stein ck. bioRxiv [Preprint]. 2023 Jul 27:2023.07.25.550482. doi: 10.1101/2023.07.25.550482. bioRxiv. 2023. PMID: 37546905 Free PMC article. Preprint.
ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma.
Neri P, Barwick BG, Jung D, Patton JC, Maity R, Tagoug I, Stein CK, Tilmont R, Leblay N, Ahn S, Lee H, Welsh SJ, Riggs DL, Stong N, Flynt E, Thakurta A, Keats JJ, Lonial S, Bergsagel PL, Boise LH, Bahlis NJ. Neri P, et al. Among authors: stein ck. Blood Cancer Discov. 2024 Jan 8;5(1):56-73. doi: 10.1158/2643-3230.BCD-23-0061. Blood Cancer Discov. 2024. PMID: 37934799 Free PMC article.
Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma.
Thongon N, Ma F, Baran N, Lockyer P, Liu J, Jackson C, Rose A, Furudate K, Wildeman B, Marchesini M, Marchica V, Storti P, Todaro G, Ganan-Gomez I, Adema V, Rodriguez-Sevilla JJ, Qing Y, Ha MJ, Fonseca R, Stein C, Class C, Tan L, Attanasio S, Garcia-Manero G, Giuliani N, Berrios Nolasco D, Santoni A, Cerchione C, Bueso-Ramos C, Konopleva M, Lorenzi P, Takahashi K, Manasanch E, Sammarelli G, Kanagal-Shamanna R, Viale A, Chesi M, Colla S. Thongon N, et al. Nat Commun. 2024 Feb 8;15(1):1203. doi: 10.1038/s41467-024-45350-8. Nat Commun. 2024. PMID: 38331987 Free PMC article.
43 results