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Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma.
Blood Cancer Discov. 2024 Jan 8;5(1):34-55. doi: 10.1158/2643-3230.BCD-23-0062.
Blood Cancer Discov. 2024.
PMID: 37767768
Free PMC article.
Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma.
Affer M, Chesi M, Chen WG, Keats JJ, Demchenko YN, Roschke AV, Van Wier S, Fonseca R, Bergsagel PL, Kuehl WM.
Affer M, et al. Among authors: demchenko yn.
Leukemia. 2014 Aug;28(8):1725-1735. doi: 10.1038/leu.2014.70. Epub 2014 Feb 12.
Leukemia. 2014.
PMID: 24518206
Free PMC article.
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Frequent occurrence of large duplications at reciprocal genomic rearrangement breakpoints in multiple myeloma and other tumors.
Demchenko Y, Roschke A, Chen WD, Asmann Y, Bergsagel PL, Kuehl WM.
Demchenko Y, et al.
Nucleic Acids Res. 2016 Sep 30;44(17):8189-98. doi: 10.1093/nar/gkw527. Epub 2016 Jun 27.
Nucleic Acids Res. 2016.
PMID: 27353332
Free PMC article.
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Classical and/or alternative NF-kappaB pathway activation in multiple myeloma.
Demchenko YN, Glebov OK, Zingone A, Keats JJ, Bergsagel PL, Kuehl WM.
Demchenko YN, et al.
Blood. 2010 Apr 29;115(17):3541-52. doi: 10.1182/blood-2009-09-243535. Epub 2010 Jan 6.
Blood. 2010.
PMID: 20053756
Free PMC article.
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Complex IGH rearrangements in multiple myeloma: Frequent detection discrepancies among three different probe sets.
Kim GY, Gabrea A, Demchenko YN, Bergsagel L, Roschke AV, Kuehl WM.
Kim GY, et al. Among authors: demchenko yn.
Genes Chromosomes Cancer. 2014 Jun;53(6):467-74. doi: 10.1002/gcc.22158. Epub 2014 Mar 3.
Genes Chromosomes Cancer. 2014.
PMID: 24585545
Free PMC article.
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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.
Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, Zhan F, Lenz G, Hanamura I, Wright G, Xiao W, Dave S, Hurt EM, Tan B, Zhao H, Stephens O, Santra M, Williams DR, Dang L, Barlogie B, Shaughnessy JD Jr, Kuehl WM, Staudt LM.
Annunziata CM, et al.
Cancer Cell. 2007 Aug;12(2):115-30. doi: 10.1016/j.ccr.2007.07.004.
Cancer Cell. 2007.
PMID: 17692804
Free PMC article.
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A critical role for the NFkB pathway in multiple myeloma.
Demchenko YN, Kuehl WM.
Demchenko YN, et al.
Oncotarget. 2010 May;1(1):59-68. doi: 10.18632/oncotarget.109.
Oncotarget. 2010.
PMID: 20890394
Free PMC article.
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Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB.
Demchenko YN, Brents LA, Li Z, Bergsagel LP, McGee LR, Kuehl MW.
Demchenko YN, et al.
Oncotarget. 2014 Jun 30;5(12):4554-66. doi: 10.18632/oncotarget.2128.
Oncotarget. 2014.
PMID: 24980832
Free PMC article.
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