Willbold D - Search Results

1

The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson's Disease.

Albus A, Kronimus Y, Burg-Roderfeld M, van der Wurp H, Willbold D, Ziehm T, Dodel R, Ross JA. Albus A, et al. Among authors: willbold d. Biomolecules. 2023 Aug 25;13(9):1303. doi: 10.3390/biom13091303. Biomolecules. 2023. PMID: 37759704 Free PMC article.

2

Differently selected D-enantiomeric peptides act on different Abeta species.

Bartnik D, Funke SA, Andrei-Selmer LC, Bacher M, Dodel R, Willbold D. Bartnik D, et al. Among authors: willbold d. Rejuvenation Res. 2010 Apr-Jun;13(2-3):202-5. doi: 10.1089/rej.2009.0924. Rejuvenation Res. 2010. PMID: 19954333

3

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease.

Jiang N, Leithold LH, Post J, Ziehm T, Mauler J, Gremer L, Cremer M, Schartmann E, Shah NJ, Kutzsche J, Langen KJ, Breitkreutz J, Willbold D, Willuweit A. Jiang N, et al. Among authors: willbold d. PLoS One. 2015 Jun 5;10(6):e0128553. doi: 10.1371/journal.pone.0128553. eCollection 2015. PLoS One. 2015. PMID: 26046986 Free PMC article.

4

Pharmacokinetic Properties of a Novel D-Peptide Developed to be Therapeutically Active Against Toxic β-Amyloid Oligomers.

Leithold LH, Jiang N, Post J, Ziehm T, Schartmann E, Kutzsche J, Shah NJ, Breitkreutz J, Langen KJ, Willuweit A, Willbold D. Leithold LH, et al. Among authors: willbold d. Pharm Res. 2016 Feb;33(2):328-36. doi: 10.1007/s11095-015-1791-2. Epub 2015 Sep 17. Pharm Res. 2016. PMID: 26381279

5

Pharmacokinetic properties of tandem d-peptides designed for treatment of Alzheimer's disease.

Leithold LH, Jiang N, Post J, Niemietz N, Schartmann E, Ziehm T, Kutzsche J, Shah NJ, Breitkreutz J, Langen KJ, Willuweit A, Willbold D. Leithold LH, et al. Among authors: willbold d. Eur J Pharm Sci. 2016 Jun 30;89:31-8. doi: 10.1016/j.ejps.2016.04.016. Epub 2016 Apr 13. Eur J Pharm Sci. 2016. PMID: 27086111

6

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination.

Klein AN, Ziehm T, Tusche M, Buitenhuis J, Bartnik D, Boeddrich A, Wiglenda T, Wanker E, Funke SA, Brener O, Gremer L, Kutzsche J, Willbold D. Klein AN, et al. Among authors: willbold d. PLoS One. 2016 Apr 22;11(4):e0153035. doi: 10.1371/journal.pone.0153035. eCollection 2016. PLoS One. 2016. PMID: 27105346 Free PMC article.

7

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

Ziehm T, Brener O, van Groen T, Kadish I, Frenzel D, Tusche M, Kutzsche J, Reiß K, Gremer L, Nagel-Steger L, Willbold D. Ziehm T, et al. Among authors: willbold d. ACS Chem Neurosci. 2016 Aug 17;7(8):1088-96. doi: 10.1021/acschemneuro.6b00047. Epub 2016 Jun 9. ACS Chem Neurosci. 2016. PMID: 27240424

8

Pyroglutamate-Modified Amyloid-β(3-42) Shows α-Helical Intermediates before Amyloid Formation.

Dammers C, Reiss K, Gremer L, Lecher J, Ziehm T, Stoldt M, Schwarten M, Willbold D. Dammers C, et al. Among authors: willbold d. Biophys J. 2017 Apr 25;112(8):1621-1633. doi: 10.1016/j.bpj.2017.03.007. Biophys J. 2017. PMID: 28445753 Free PMC article.

9

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

Klein AN, Ziehm T, van Groen T, Kadish I, Elfgen A, Tusche M, Thomaier M, Reiss K, Brener O, Gremer L, Kutzsche J, Willbold D. Klein AN, et al. Among authors: willbold d. ACS Chem Neurosci. 2017 Sep 20;8(9):1889-1900. doi: 10.1021/acschemneuro.7b00045. Epub 2017 Jun 23. ACS Chem Neurosci. 2017. PMID: 28581708

10

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.

van Groen T, Schemmert S, Brener O, Gremer L, Ziehm T, Tusche M, Nagel-Steger L, Kadish I, Schartmann E, Elfgen A, Jürgens D, Willuweit A, Kutzsche J, Willbold D. van Groen T, et al. Among authors: willbold d. Sci Rep. 2017 Nov 24;7(1):16275. doi: 10.1038/s41598-017-16565-1. Sci Rep. 2017. PMID: 29176708 Free PMC article.

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