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Functional characterization of a single nucleotide polymorphism associated with Alzheimer's disease in a hiPSC-based neuron model.
Stolzenburg LR, Esmaeeli S, Kulkarni AS, Murphy E, Kwon T, Preiss C, Bahnassawy L, Stender JD, Manos JD, Reinhardt P, Rahimov F, Waring JF, Ramathal CY. Stolzenburg LR, et al. Among authors: reinhardt p. PLoS One. 2023 Sep 26;18(9):e0291029. doi: 10.1371/journal.pone.0291029. eCollection 2023. PLoS One. 2023. PMID: 37751459 Free PMC article.
Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
Popescu AS, Butler CA, Allendorf DH, Piers TM, Mallach A, Roewe J, Reinhardt P, Cinti A, Redaelli L, Boudesco C, Pradier L, Pocock JM, Thornton P, Brown GC. Popescu AS, et al. Among authors: reinhardt p. Glia. 2023 Apr;71(4):974-990. doi: 10.1002/glia.24318. Epub 2022 Dec 8. Glia. 2023. PMID: 36480007 Free PMC article.
Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation.
Reinhardt L, Musacchio F, Bichmann M, Behrendt A, Ercan-Herbst E, Stein J, Becher I, Haberkant P, Mader J, Schöndorf DC, Schmitt M, Korffmann J, Reinhardt P, Pohl C, Savitski M, Klein C, Gasparini L, Fuhrmann M, Ehrnhoefer DE. Reinhardt L, et al. Among authors: reinhardt p. Neurobiol Dis. 2023 Jun 15;182:106126. doi: 10.1016/j.nbd.2023.106126. Epub 2023 Apr 20. Neurobiol Dis. 2023. PMID: 37086756 Free article.
Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation.
Hollunder B, Ostrem JL, Sahin IA, Rajamani N, Oxenford S, Butenko K, Neudorfer C, Reinhardt P, Zvarova P, Polosan M, Akram H, Vissani M, Zhang C, Sun B, Navratil P, Reich MM, Volkmann J, Yeh FC, Baldermann JC, Dembek TA, Visser-Vandewalle V, Alho EJL, Franceschini PR, Nanda P, Finke C, Kühn AA, Dougherty DD, Richardson RM, Bergman H, DeLong MR, Mazzoni A, Romito LM, Tyagi H, Zrinzo L, Joyce EM, Chabardes S, Starr PA, Li N, Horn A. Hollunder B, et al. Among authors: reinhardt p. Nat Neurosci. 2024 Mar;27(3):573-586. doi: 10.1038/s41593-024-01570-1. Epub 2024 Feb 22. Nat Neurosci. 2024. PMID: 38388734 Free PMC article.
Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations.
Bahnassawy L, Nicolaisen N, Untucht C, Mielich-Süss B, Reinhardt L, Ried JS, Morawe MP, Geist D, Finck A, Käfer E, Korffmann J, Townsend M, Ravikumar B, Lakics V, Cik M, Reinhardt P. Bahnassawy L, et al. Among authors: reinhardt p. SLAS Discov. 2024 Mar;29(2):100137. doi: 10.1016/j.slasd.2023.12.009. Epub 2023 Dec 19. SLAS Discov. 2024. PMID: 38128829 Free article.
131 results