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Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water.
Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0035023. doi: 10.1128/aac.00350-23. Epub 2023 Sep 26.
Antimicrob Agents Chemother. 2023.
PMID: 37750722
Free PMC article.
Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam.
Alsenani TA, Viviani SL, Kumar V, Taracila MA, Bethel CR, Barnes MD, Papp-Wallace KM, Shields RK, Nguyen MH, Clancy CJ, Bonomo RA, van den Akker F.
Alsenani TA, et al. Among authors: viviani sl.
Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0241421. doi: 10.1128/aac.02414-21. Epub 2022 Mar 28.
Antimicrob Agents Chemother. 2022.
PMID: 35341315
Free PMC article.
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Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3.
Kumar V, Viviani SL, Ismail J, Agarwal S, Bonomo RA, van den Akker F.
Kumar V, et al. Among authors: viviani sl.
PLoS One. 2021 Oct 15;16(10):e0258359. doi: 10.1371/journal.pone.0258359. eCollection 2021.
PLoS One. 2021.
PMID: 34653211
Free PMC article.
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