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Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water.
Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0035023. doi: 10.1128/aac.00350-23. Epub 2023 Sep 26.
Antimicrob Agents Chemother. 2023.
PMID: 37750722
Free PMC article.
Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses.
Alsenani TA, Rodríguez MM, Ghiglione B, Taracila MA, Mojica MF, Rojas LJ, Hujer AM, Gutkind G, Bethel CR, Rather PN, Introvigne ML, Prati F, Caselli E, Power P, van den Akker F, Bonomo RA.
Alsenani TA, et al.
Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0093022. doi: 10.1128/aac.00930-22. Epub 2023 Jan 5.
Antimicrob Agents Chemother. 2023.
PMID: 36602311
Free PMC article.
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Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam.
Alsenani TA, Viviani SL, Kumar V, Taracila MA, Bethel CR, Barnes MD, Papp-Wallace KM, Shields RK, Nguyen MH, Clancy CJ, Bonomo RA, van den Akker F.
Alsenani TA, et al.
Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0241421. doi: 10.1128/aac.02414-21. Epub 2022 Mar 28.
Antimicrob Agents Chemother. 2022.
PMID: 35341315
Free PMC article.
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