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Synthesis of portimines reveals the basis of their anti-cancer activity.
Tang J, Li W, Chiu TY, Martínez-Peña F, Luo Z, Chong CT, Wei Q, Gazaniga N, West TJ, See YY, Lairson LL, Parker CG, Baran PS. Tang J, et al. Among authors: lairson ll. Nature. 2023 Oct;622(7983):507-513. doi: 10.1038/s41586-023-06535-1. Epub 2023 Sep 20. Nature. 2023. PMID: 37730997
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Chin EN, Yu C, Vartabedian VF, Jia Y, Kumar M, Gamo AM, Vernier W, Ali SH, Kissai M, Lazar DC, Nguyen N, Pereira LE, Benish B, Woods AK, Joseph SB, Chu A, Johnson KA, Sander PN, Martínez-Peña F, Hampton EN, Young TS, Wolan DW, Chatterjee AK, Schultz PG, Petrassi HM, Teijaro JR, Lairson LL. Chin EN, et al. Among authors: lairson ll. Science. 2020 Aug 21;369(6506):993-999. doi: 10.1126/science.abb4255. Science. 2020. PMID: 32820126
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux.
Spangenberg SH, Palermo A, Gazaniga NR, Martínez-Peña F, Guijas C, Chin EN, Rinschen MM, Sander PN, Webb B, Pereira LE, Jia Y, Meitz L, Siuzdak G, Lairson LL. Spangenberg SH, et al. Among authors: lairson ll. Cell Chem Biol. 2023 Sep 21;30(9):1115-1134.e10. doi: 10.1016/j.chembiol.2023.06.016. Epub 2023 Jul 18. Cell Chem Biol. 2023. PMID: 37467751
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization.
Bertin P, Rector-Brooks J, Sharma D, Gaudelet T, Anighoro A, Gross T, Martínez-Peña F, Tang EL, Suraj MS, Regep C, Hayter JBR, Korablyov M, Valiante N, van der Sloot A, Tyers M, Roberts CES, Bronstein MM, Lairson LL, Taylor-King JP, Bengio Y. Bertin P, et al. Among authors: lairson ll. Cell Rep Methods. 2023 Oct 23;3(10):100599. doi: 10.1016/j.crmeth.2023.100599. Epub 2023 Oct 4. Cell Rep Methods. 2023. PMID: 37797618 Free PMC article.
63 results