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Rapid manufacturing of non-activated potent CAR T cells.
Ghassemi S, Durgin JS, Nunez-Cruz S, Patel J, Leferovich J, Pinzone M, Shen F, Cummins KD, Plesa G, Cantu VA, Reddy S, Bushman FD, Gill SI, O'Doherty U, O'Connor RS, Milone MC. Ghassemi S, et al. Among authors: leferovich j. Nat Biomed Eng. 2022 Feb;6(2):118-128. doi: 10.1038/s41551-021-00842-6. Epub 2022 Feb 21. Nat Biomed Eng. 2022. PMID: 35190680 Free PMC article.
CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production.
Garcia-Canaveras JC, Heo D, Trefely S, Leferovich J, Xu C, Philipson BI, Ghassemi S, Milone MC, Moon EK, Snyder NW, June CH, Rabinowitz JD, O'Connor RS. Garcia-Canaveras JC, et al. Among authors: leferovich j. Cells. 2021 Sep 6;10(9):2334. doi: 10.3390/cells10092334. Cells. 2021. PMID: 34571983 Free PMC article.
Itacitinib (INCB039110), a JAK1 Inhibitor, Reduces Cytokines Associated with Cytokine Release Syndrome Induced by CAR T-cell Therapy.
Huarte E, O'Connor RS, Peel MT, Nunez-Cruz S, Leferovich J, Juvekar A, Yang YO, Truong L, Huang T, Naim A, Milone MC, Smith PA. Huarte E, et al. Among authors: leferovich j. Clin Cancer Res. 2020 Dec 1;26(23):6299-6309. doi: 10.1158/1078-0432.CCR-20-1739. Epub 2020 Sep 30. Clin Cancer Res. 2020. PMID: 32998963 Free PMC article.
Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design.
Ghassemi S, Martinez-Becerra FJ, Master AM, Richman SA, Heo D, Leferovich J, Tu Y, García-Cañaveras JC, Ayari A, Lu Y, Wang A, Rabinowitz JD, Milone MC, June CH, O'Connor RS. Ghassemi S, et al. Among authors: leferovich j. Mol Ther Methods Clin Dev. 2020 Jul 9;18:595-606. doi: 10.1016/j.omtm.2020.07.008. eCollection 2020 Sep 11. Mol Ther Methods Clin Dev. 2020. PMID: 32775494 Free PMC article.
Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells.
Ghassemi S, Nunez-Cruz S, O'Connor RS, Fraietta JA, Patel PR, Scholler J, Barrett DM, Lundh SM, Davis MM, Bedoya F, Zhang C, Leferovich J, Lacey SF, Levine BL, Grupp SA, June CH, Melenhorst JJ, Milone MC. Ghassemi S, et al. Among authors: leferovich j. Cancer Immunol Res. 2018 Sep;6(9):1100-1109. doi: 10.1158/2326-6066.CIR-17-0405. Epub 2018 Jul 20. Cancer Immunol Res. 2018. PMID: 30030295 Free PMC article. Clinical Trial.
Drug-induced regeneration in adult mice.
Zhang Y, Strehin I, Bedelbaeva K, Gourevitch D, Clark L, Leferovich J, Messersmith PB, Heber-Katz E. Zhang Y, et al. Among authors: leferovich j. Sci Transl Med. 2015 Jun 3;7(290):290ra92. doi: 10.1126/scitranslmed.3010228. Sci Transl Med. 2015. PMID: 26041709 Free PMC article.
Keratin gene expression profiles after digit amputation in C57BL/6 vs. regenerative MRL mice imply an early regenerative keratinocyte activated-like state.
Cheng CH, Leferovich J, Zhang XM, Bedelbaeva K, Gourevitch D, Hatcher CJ, Basson CT, Heber-Katz E, Marx KA. Cheng CH, et al. Among authors: leferovich j. Physiol Genomics. 2013 Jun 3;45(11):409-21. doi: 10.1152/physiolgenomics.00142.2012. Epub 2013 Mar 19. Physiol Genomics. 2013. PMID: 23512742 Free PMC article.
35 results