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Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.
Yuan Z, van Delft MF, Li MX, Sumardy F, Smith BJ, Huang DCS, Lessene G, Khakam Y, Jin R, He S, Smith NA, Birkinshaw RW, Czabotar PE, Dewson G. Yuan Z, et al. Among authors: lessene g. PLoS Biol. 2024 May 2;22(5):e3002617. doi: 10.1371/journal.pbio.3002617. eCollection 2024 May. PLoS Biol. 2024. PMID: 38696533 Free PMC article.
Correction: ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors Across Tumor Types.
Chüeh AC, Tse JWT, Dickinson M, Ioannidis P, Jenkins L, Togel L, Tan B, Luk I, Davalos-Salas M, Nightingale R, Thompson MR, Williams BRG, Lessene G, Lee EF, Fairlie WD, Dhillon AS, Mariadason JM. Chüeh AC, et al. Among authors: lessene g. Clin Cancer Res. 2023 Sep 15;29(18):3826. doi: 10.1158/1078-0432.CCR-23-2100. Clin Cancer Res. 2023. PMID: 37712140 No abstract available.
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase.
Pierotti CL, Jacobsen AV, Grohmann C, Dempsey RK, Etemadi N, Hildebrand JM, Fitzgibbon C, Young SN, Davies KA, Kersten WJA, Silke J, Lowes KN, Jousset Sabroux H, Huang DCS, van Delft MF, Murphy JM, Lessene G. Pierotti CL, et al. Among authors: lessene g. Biochem J. 2023 May 15;480(9):665-684. doi: 10.1042/BCJ20230035. Biochem J. 2023. PMID: 37115711 Free PMC article.
Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Wang Z, Hu H, Heitink L, Rogers K, You Y, Tan T, Suen CLW, Garnham A, Chen H, Lieschke E, Diepstraten ST, Chang C, Chen T, Moujalled D, Sutherland K, Lessene G, Sieber OM, Visvader J, Kelly GL, Strasser A. Wang Z, et al. Among authors: lessene g. Cell Death Differ. 2023 Apr;30(4):1096. doi: 10.1038/s41418-023-01137-w. Cell Death Differ. 2023. PMID: 36828917 Free PMC article. No abstract available.
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors.
Gardner CR, Davies KA, Zhang Y, Brzozowski M, Czabotar PE, Murphy JM, Lessene G. Gardner CR, et al. Among authors: lessene g. J Med Chem. 2023 Feb 23;66(4):2361-2385. doi: 10.1021/acs.jmedchem.2c01621. Epub 2023 Feb 13. J Med Chem. 2023. PMID: 36781172 Free PMC article. Review.
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Wang Z, Hu H, Heitink L, Rogers K, You Y, Tan T, Suen CLW, Garnham A, Chen H, Lieschke E, Diepstraten ST, Chang C, Chen T, Moujalled D, Sutherland K, Lessene G, Sieber OM, Visvader J, Kelly GL, Strasser A. Wang Z, et al. Among authors: lessene g. Cell Death Differ. 2023 Apr;30(4):1033-1046. doi: 10.1038/s41418-023-01122-3. Epub 2023 Feb 4. Cell Death Differ. 2023. PMID: 36739334 Free PMC article.
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.
Moujalled DM, Brown FC, Chua CC, Dengler MA, Pomilio G, Anstee NS, Litalien V, Thompson E, Morley T, MacRaild S, Tiong IS, Morris R, Dun K, Zordan A, Shah J, Banquet S, Halilovic E, Morris E, Herold MJ, Lessene G, Adams JM, Huang DCS, Roberts AW, Blombery P, Wei AH. Moujalled DM, et al. Among authors: lessene g. Blood. 2023 Feb 9;141(6):634-644. doi: 10.1182/blood.2022016090. Blood. 2023. PMID: 36219880 Free PMC article.
Inhibitors of SARS-CoV-2 PLpro.
Calleja DJ, Lessene G, Komander D. Calleja DJ, et al. Among authors: lessene g. Front Chem. 2022 Apr 26;10:876212. doi: 10.3389/fchem.2022.876212. eCollection 2022. Front Chem. 2022. PMID: 35559224 Free PMC article. Review.
Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors.
Calleja DJ, Kuchel N, Lu BGC, Birkinshaw RW, Klemm T, Doerflinger M, Cooney JP, Mackiewicz L, Au AE, Yap YQ, Blackmore TR, Katneni K, Crighton E, Newman J, Jarman KE, Call MJ, Lechtenberg BC, Czabotar PE, Pellegrini M, Charman SA, Lowes KN, Mitchell JP, Nachbur U, Lessene G, Komander D. Calleja DJ, et al. Among authors: lessene g. Front Chem. 2022 Apr 12;10:861209. doi: 10.3389/fchem.2022.861209. eCollection 2022. Front Chem. 2022. PMID: 35494659 Free PMC article.
85 results