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Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.
Lee CS, Jung SY, Yee RSZ, Agha NH, Hong J, Chang T, Babcock LW, Fleischman JD, Clayton B, Hanna AD, Ward CS, Lanza D, Hurley AE, Zhang P, Wehrens XHT, Lagor WR, Rodney GG, Hamilton SL. Lee CS, et al. Among authors: rodney gg. Commun Biol. 2023 Sep 14;6(1):942. doi: 10.1038/s42003-023-05330-y. Commun Biol. 2023. PMID: 37709832 Free PMC article.
A chemical chaperone improves muscle function in mice with a RyR1 mutation.
Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. Lee CS, et al. Among authors: rodney gg. Nat Commun. 2017 Mar 24;8:14659. doi: 10.1038/ncomms14659. Nat Commun. 2017. PMID: 28337975 Free PMC article.
Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.
Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL. Lee CS, et al. Among authors: rodney gg. Skelet Muscle. 2015 Jan 29;5:4. doi: 10.1186/s13395-014-0027-1. eCollection 2015. Skelet Muscle. 2015. PMID: 25717360 Free PMC article.
A microtubule-connexin-43 regulatory link suppresses arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy mice.
Himelman E, Nouet J, Lillo MA, Chong A, Zhou D, Wehrens XHT, Rodney GG, Xie LH, Shirokova N, Contreras JE, Fraidenraich D. Himelman E, et al. Among authors: rodney gg. Am J Physiol Heart Circ Physiol. 2022 Nov 1;323(5):H983-H995. doi: 10.1152/ajpheart.00179.2022. Epub 2022 Oct 7. Am J Physiol Heart Circ Physiol. 2022. PMID: 36206047 Free PMC article.
Regulation of RYR1 activity by Ca(2+) and calmodulin.
Rodney GG, Williams BY, Strasburg GM, Beckingham K, Hamilton SL. Rodney GG, et al. Biochemistry. 2000 Jul 4;39(26):7807-12. doi: 10.1021/bi0005660. Biochemistry. 2000. PMID: 10869186
Lobe-dependent regulation of ryanodine receptor type 1 by calmodulin.
Xiong LW, Newman RA, Rodney GG, Thomas O, Zhang JZ, Persechini A, Shea MA, Hamilton SL. Xiong LW, et al. Among authors: rodney gg. J Biol Chem. 2002 Oct 25;277(43):40862-70. doi: 10.1074/jbc.M206763200. Epub 2002 Aug 15. J Biol Chem. 2002. PMID: 12185083 Free article.
Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy.
Liu R, Lee J, Kim BS, Wang Q, Buxton SK, Balasubramanyam N, Kim JJ, Dong J, Zhang A, Li S, Gupte AA, Hamilton DJ, Martin JF, Rodney GG, Coarfa C, Wehrens XH, Yechoor VK, Moulik M. Liu R, et al. Among authors: rodney gg. JCI Insight. 2017 Sep 7;2(17):e93343. doi: 10.1172/jci.insight.93343. eCollection 2017 Sep 7. JCI Insight. 2017. PMID: 28878117 Free PMC article.
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