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The design, synthesis, and inhibition of Clostridioides difficile spore germination by acyclic and bicyclic tertiary amide analogs of cholate.
Eur J Med Chem. 2023 Dec 5;261:115788. doi: 10.1016/j.ejmech.2023.115788. Epub 2023 Sep 4.
Eur J Med Chem. 2023.
PMID: 37703709
Studies on the Importance of the 7α-, and 12α- hydroxyl groups of N-Aryl-3α,7α,12α-trihydroxy-5β-cholan-24-amides on their Antigermination Activity Against a Hypervirulent Strain of Clostridioides (Clostridium) difficile.
Sharma SK, Yip C, Simon MP, Phan J, Abel-Santos E, Firestine SM.
Sharma SK, et al.
Bioorg Med Chem. 2021 Dec 15;52:116503. doi: 10.1016/j.bmc.2021.116503. Epub 2021 Nov 10.
Bioorg Med Chem. 2021.
PMID: 34837818
Free PMC article.
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Mechanism of germination inhibition of Clostridioides difficile spores by an aniline substituted cholate derivative (CaPA).
Yip C, Phan JR, Abel-Santos E.
Yip C, et al. Among authors: phan jr.
J Antibiot (Tokyo). 2023 Jun;76(6):335-345. doi: 10.1038/s41429-023-00612-3. Epub 2023 Apr 4.
J Antibiot (Tokyo). 2023.
PMID: 37016015
Free PMC article.
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An Aniline-Substituted Bile Salt Analog Protects both Mice and Hamsters from Multiple Clostridioides difficile Strains.
Phan JR, Do DM, Truong MC, Ngo C, Phan JH, Sharma SK, Schilke A, Mefferd CC, Villarama JV, Lai D, Consul A, Hedlund BP, Firestine SM, Abel-Santos E.
Phan JR, et al.
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0143521. doi: 10.1128/AAC.01435-21. Epub 2021 Nov 15.
Antimicrob Agents Chemother. 2022.
PMID: 34780262
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A High-Fat/High-Protein, Atkins-Type Diet Exacerbates Clostridioides (Clostridium) difficile Infection in Mice, whereas a High-Carbohydrate Diet Protects.
Mefferd CC, Bhute SS, Phan JR, Villarama JV, Do DM, Alarcia S, Abel-Santos E, Hedlund BP.
Mefferd CC, et al. Among authors: phan jr.
mSystems. 2020 Feb 11;5(1):e00765-19. doi: 10.1128/mSystems.00765-19.
mSystems. 2020.
PMID: 32047064
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A High-Carbohydrate Diet Prolongs Dysbiosis and Clostridioides difficile Carriage and Increases Delayed Mortality in a Hamster Model of Infection.
Bhute SS, Mefferd CC, Phan JR, Ahmed M, Fox-King AE, Alarcia S, Villarama JV, Abel-Santos E, Hedlund BP.
Bhute SS, et al. Among authors: phan jr.
Microbiol Spectr. 2022 Aug 31;10(4):e0180421. doi: 10.1128/spectrum.01804-21. Epub 2022 Jun 16.
Microbiol Spectr. 2022.
PMID: 35708337
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Effect of the Synthetic Bile Salt Analog CamSA on the Hamster Model of Clostridium difficile Infection.
Howerton A, Seymour CO, Murugapiran SK, Liao Z, Phan JR, Estrada A, Wagner AJ, Mefferd CC, Hedlund BP, Abel-Santos E.
Howerton A, et al. Among authors: phan jr.
Antimicrob Agents Chemother. 2018 Sep 24;62(10):e02251-17. doi: 10.1128/AAC.02251-17. Print 2018 Oct.
Antimicrob Agents Chemother. 2018.
PMID: 30012758
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