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A New Avenue for Enhanced Treatment of Hyperuricemia and Oxidative Stress: Design, Synthesis and Biological Evaluation of Some Novel Mutual Prodrugs Involving Febuxostat Conjugated with Different Antioxidants.
Bioorg Chem. 2023 Nov;140:106818. doi: 10.1016/j.bioorg.2023.106818. Epub 2023 Aug 28.
Bioorg Chem. 2023.
PMID: 37688830
Febuxostat-based amides and some derived heterocycles targeting xanthine oxidase and COX inhibition. Synthesis, in vitro and in vivo biological evaluation, molecular modeling and in silico ADMET studies.
Rashad AY, Kassab SE, Daabees HG, Abdel Moneim AE, Rostom SAF.
Rashad AY, et al.
Bioorg Chem. 2021 Aug;113:104948. doi: 10.1016/j.bioorg.2021.104948. Epub 2021 Apr 27.
Bioorg Chem. 2021.
PMID: 34052736
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Towards the Development of Dual Hypouricemic and Anti-inflammatory Candidates: Design, Synthesis, Stability Studies and Biological Evaluation of Some Mutual Ester Prodrugs of Febuxostat-NSAIDs.
Rashad AY, Daabees HG, Elagawany M, Shahin M, Abdel Moneim AE, Rostom SAF.
Rashad AY, et al.
Bioorg Chem. 2023 Jun;135:106502. doi: 10.1016/j.bioorg.2023.106502. Epub 2023 Mar 31.
Bioorg Chem. 2023.
PMID: 37030108
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