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Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.
Tharp KM, Kersten K, Maller O, Timblin GA, Stashko C, Canale FP, Menjivar RE, Hayward MK, Berestjuk I, Ten Hoeve J, Samad B, Ironside AJ, di Magliano MP, Muir A, Geiger R, Combes AJ, Weaver VM. Tharp KM, et al. Among authors: timblin ga. Nat Cancer. 2024 Jun 3. doi: 10.1038/s43018-024-00775-4. Online ahead of print. Nat Cancer. 2024. PMID: 38831058
The microenvironment dictates glycocalyx construction and immune surveillance.
Tharp KM, Park S, Timblin GA, Richards AL, Berg JA, Twells NM, Riley NM, Peltan EL, Shon DJ, Stevenson E, Tsui K, Palomba F, Lefebvre AEYT, Soens RW, Ayad NME, Hoeve-Scott JT, Healy K, Digman M, Dillin A, Bertozzi CR, Swaney DL, Mahal LK, Cantor JR, Paszek MJ, Weaver VM. Tharp KM, et al. Among authors: timblin ga. Res Sq [Preprint]. 2023 Aug 16:rs.3.rs-3164966. doi: 10.21203/rs.3.rs-3164966/v1. Res Sq. 2023. PMID: 37645943 Free PMC article. Preprint.
Mitohormesis reprogrammes macrophage metabolism to enforce tolerance.
Timblin GA, Tharp KM, Ford B, Winchester JM, Wang J, Zhu S, Khan RI, Louie SK, Iavarone AT, Ten Hoeve J, Nomura DK, Stahl A, Saijo K. Timblin GA, et al. Nat Metab. 2021 May;3(5):618-635. doi: 10.1038/s42255-021-00392-w. Epub 2021 May 20. Nat Metab. 2021. PMID: 34031590 Free PMC article.
Adhesion-mediated mechanosignaling forces mitohormesis.
Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM. Tharp KM, et al. Among authors: timblin ga. Cell Metab. 2021 Jul 6;33(7):1322-1341.e13. doi: 10.1016/j.cmet.2021.04.017. Epub 2021 May 20. Cell Metab. 2021. PMID: 34019840 Free PMC article.
Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues.
Tharp KM, Kang MS, Timblin GA, Dempersmier J, Dempsey GE, Zushin PH, Benavides J, Choi C, Li CX, Jha AK, Kajimura S, Healy KE, Sul HS, Saijo K, Kumar S, Stahl A. Tharp KM, et al. Among authors: timblin ga. Cell Metab. 2018 Mar 6;27(3):602-615.e4. doi: 10.1016/j.cmet.2018.02.005. Cell Metab. 2018. PMID: 29514068 Free PMC article.
11 results