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Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1.
Schwarzer A, Oliveira M, Kleppa MJ, Slattery SD, Anantha A, Cooper A, Hannink M, Schambach A, Dörrie A, Kotlyarov A, Gaestel M, Hembrough T, Levine J, Luther M, Stocum M, Stiles L, Weinstock DM, Liesa M, Kostura MJ. Schwarzer A, et al. Among authors: liesa m. Mol Cancer Ther. 2023 Nov 1;22(11):1290-1303. doi: 10.1158/1535-7163.MCT-22-0718. Mol Cancer Ther. 2023. PMID: 37643767 Free PMC article.
Genes involved in mitochondrial biogenesis/function are induced in response to bilio-pancreatic diversion in morbidly obese individuals with normal glucose tolerance but not in type 2 diabetic patients.
Hernández-Alvarez MI, Chiellini C, Manco M, Naon D, Liesa M, Palacín M, Mingrone G, Zorzano A. Hernández-Alvarez MI, et al. Among authors: liesa m. Diabetologia. 2009 Aug;52(8):1618-27. doi: 10.1007/s00125-009-1403-y. Epub 2009 Jun 6. Diabetologia. 2009. PMID: 19504086 Free article.
Telomere dysfunction induces metabolic and mitochondrial compromise.
Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Sahin E, et al. Among authors: liesa m. Nature. 2011 Feb 17;470(7334):359-65. doi: 10.1038/nature09787. Epub 2011 Feb 9. Nature. 2011. PMID: 21307849 Free PMC article.
High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II.
Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. Sverdlov AL, et al. Among authors: liesa m. J Mol Cell Cardiol. 2015 Jan;78:165-73. doi: 10.1016/j.yjmcc.2014.07.018. Epub 2014 Aug 7. J Mol Cell Cardiol. 2015. PMID: 25109264 Free PMC article.
Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.
Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN. Wilson AA, et al. Among authors: liesa m. Stem Cell Reports. 2015 May 12;4(5):873-85. doi: 10.1016/j.stemcr.2015.02.021. Epub 2015 Apr 2. Stem Cell Reports. 2015. PMID: 25843048 Free PMC article.
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.
Hernández-Alvarez MI, Thabit H, Burns N, Shah S, Brema I, Hatunic M, Finucane F, Liesa M, Chiellini C, Naon D, Zorzano A, Nolan JJ. Hernández-Alvarez MI, et al. Among authors: liesa m. Diabetes Care. 2010 Mar;33(3):645-51. doi: 10.2337/dc09-1305. Epub 2009 Dec 23. Diabetes Care. 2010. PMID: 20032281 Free PMC article. Clinical Trial.
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