Martin NI - Search Results

1

MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer.

Bhin J, Yemelyanenko J, Chao X, Klarenbeek S, Opdam M, Malka Y, Hoekman L, Kruger D, Bleijerveld O, Brambillasca CS, Sprengers J, Siteur B, Annunziato S, van Haren MJ, Martin NI, van de Ven M, Peters D, Agami R, Linn SC, Boven E, Altelaar M, Jonkers J, Zingg D, Wessels LFA. Bhin J, et al. Among authors: martin ni. J Exp Med. 2023 Nov 6;220(11):e20211743. doi: 10.1084/jem.20211743. Epub 2023 Aug 29. J Exp Med. 2023. PMID: 37642941 Free PMC article.

2

A concise preparation of the fluorescent amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine and extension of its utility in solid phase peptide synthesis.

Koopmans T, van Haren M, van Ufford LQ, Beekman JM, Martin NI. Koopmans T, et al. Among authors: martin ni. Bioorg Med Chem. 2013 Jan 15;21(2):553-9. doi: 10.1016/j.bmc.2012.10.055. Epub 2012 Nov 21. Bioorg Med Chem. 2013. PMID: 23238078

3

Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites.

van Haren M, van Ufford LQ, Moret EE, Martin NI. van Haren M, et al. Among authors: martin ni. Org Biomol Chem. 2015 Jan 14;13(2):549-60. doi: 10.1039/c4ob01734j. Org Biomol Chem. 2015. PMID: 25380215

4

A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase.

van Haren MJ, Sastre Toraño J, Sartini D, Emanuelli M, Parsons RB, Martin NI. van Haren MJ, et al. Among authors: martin ni. Biochemistry. 2016 Sep 20;55(37):5307-15. doi: 10.1021/acs.biochem.6b00733. Epub 2016 Sep 9. Biochemistry. 2016. PMID: 27570878

5

Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.

van Haren MJ, Marechal N, Troffer-Charlier N, Cianciulli A, Sbardella G, Cavarelli J, Martin NI. van Haren MJ, et al. Among authors: martin ni. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3625-3630. doi: 10.1073/pnas.1618401114. Epub 2017 Mar 22. Proc Natl Acad Sci U S A. 2017. PMID: 28330993 Free PMC article.

6

Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state.

van Haren MJ, Taig R, Kuppens J, Sastre Toraño J, Moret EE, Parsons RB, Sartini D, Emanuelli M, Martin NI. van Haren MJ, et al. Among authors: martin ni. Org Biomol Chem. 2017 Aug 9;15(31):6656-6667. doi: 10.1039/c7ob01357d. Org Biomol Chem. 2017. PMID: 28758655

7

Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity.

Gao Y, van Haren MJ, Moret EE, Rood JJM, Sartini D, Salvucci A, Emanuelli M, Craveur P, Babault N, Jin J, Martin NI. Gao Y, et al. Among authors: martin ni. J Med Chem. 2019 Jul 25;62(14):6597-6614. doi: 10.1021/acs.jmedchem.9b00413. Epub 2019 Jul 12. J Med Chem. 2019. PMID: 31265285 Free PMC article.

8

Peptidic transition state analogues as PRMT inhibitors.

Zhang Y, van Haren MJ, Martin NI. Zhang Y, et al. Among authors: martin ni. Methods. 2020 Mar 15;175:24-29. doi: 10.1016/j.ymeth.2019.08.003. Epub 2019 Aug 14. Methods. 2020. PMID: 31421210 Free article.

9

Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N'-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1.

Tehrani KHME, Fu H, Brüchle NC, Mashayekhi V, Prats Luján A, van Haren MJ, Poelarends GJ, Martin NI. Tehrani KHME, et al. Among authors: martin ni. Chem Commun (Camb). 2020 Mar 10;56(20):3047-3049. doi: 10.1039/d0cc00356e. Chem Commun (Camb). 2020. PMID: 32048688

10

Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem.

Tehrani KHME, Brüchle NC, Wade N, Mashayekhi V, Pesce D, van Haren MJ, Martin NI. Tehrani KHME, et al. Among authors: martin ni. ACS Infect Dis. 2020 Jun 12;6(6):1366-1371. doi: 10.1021/acsinfecdis.9b00459. Epub 2020 Apr 3. ACS Infect Dis. 2020. PMID: 32227874 Free PMC article.

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