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Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples.
J Med Chem. 2023 Sep 14;66(17):11843-11854. doi: 10.1021/acs.jmedchem.3c00426. Epub 2023 Aug 26.
J Med Chem. 2023.
PMID: 37632447
Free PMC article.
Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.
Muratspahić E, Deibler K, Han J, Tomašević N, Jadhav KB, Olivé-Marti AL, Hochrainer N, Hellinger R, Koehbach J, Fay JF, Rahman MH, Hegazy L, Craven TW, Varga BR, Bhardwaj G, Appourchaux K, Majumdar S, Muttenthaler M, Hosseinzadeh P, Craik DJ, Spetea M, Che T, Baker D, Gruber CW.
Muratspahić E, et al. Among authors: hochrainer n.
Nat Commun. 2023 Dec 6;14(1):8064. doi: 10.1038/s41467-023-43718-w.
Nat Commun. 2023.
PMID: 38052802
Free PMC article.
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In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin-Ranatensin Hybrid Peptide.
Hochrainer N, Serafin P, D'Ingiullo S, Mollica A, Granica S, Brytan M, Kleczkowska P, Spetea M.
Hochrainer N, et al.
Int J Mol Sci. 2024 Apr 3;25(7):4007. doi: 10.3390/ijms25074007.
Int J Mol Sci. 2024.
PMID: 38612817
Free PMC article.
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