Alexopoulos LG - Search Results

1

A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression.

Imoto H, Rauch N, Neve AJ, Khorsand F, Kreileder M, Alexopoulos LG, Rauch J, Okada M, Kholodenko BN, Rukhlenko OS. Imoto H, et al. Among authors: alexopoulos lg. Biomolecules. 2023 Aug 2;13(8):1212. doi: 10.3390/biom13081212. Biomolecules. 2023. PMID: 37627277 Free PMC article.

2

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling.

Rukhlenko OS, Khorsand F, Krstic A, Rozanc J, Alexopoulos LG, Rauch N, Erickson KE, Hlavacek WS, Posner RG, Gómez-Coca S, Rosta E, Fitzgibbon C, Matallanas D, Rauch J, Kolch W, Kholodenko BN. Rukhlenko OS, et al. Among authors: alexopoulos lg. Cell Syst. 2018 Aug 22;7(2):161-179.e14. doi: 10.1016/j.cels.2018.06.002. Epub 2018 Jul 11. Cell Syst. 2018. PMID: 30007540 Free PMC article.

3

Network-based technologies for early drug discovery.

Fotis C, Antoranz A, Hatziavramidis D, Sakellaropoulos T, Alexopoulos LG. Fotis C, et al. Among authors: alexopoulos lg. Drug Discov Today. 2018 Mar;23(3):626-635. doi: 10.1016/j.drudis.2017.12.001. Epub 2017 Dec 30. Drug Discov Today. 2018. PMID: 29294361 Review.

4

COMBSecretomics: A pragmatic methodological framework for higher-order drug combination analysis using secretomics.

Chantzi E, Neidlin M, Macheras GA, Alexopoulos LG, Gustafsson MG. Chantzi E, et al. Among authors: alexopoulos lg. PLoS One. 2020 May 14;15(5):e0232989. doi: 10.1371/journal.pone.0232989. eCollection 2020. PLoS One. 2020. PMID: 32407402 Free PMC article.

5

Multi-tissue network analysis for drug prioritization in knee osteoarthritis.

Neidlin M, Dimitrakopoulou S, Alexopoulos LG. Neidlin M, et al. Among authors: alexopoulos lg. Sci Rep. 2019 Oct 23;9(1):15176. doi: 10.1038/s41598-019-51627-6. Sci Rep. 2019. PMID: 31645614 Free PMC article.

6

Construction of signaling pathways and identification of drug effects on the liver cancer cell HepG2.

Alexopoulos LG, Melas IN, Chairakaki AD, Saez-Rodriguez J, Mitsos A. Alexopoulos LG, et al. Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:6717-20. doi: 10.1109/IEMBS.2010.5626246. Annu Int Conf IEEE Eng Med Biol Soc. 2010. PMID: 21096084

7

Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma.

Skoko J, Rožanc J, Charles EM, Alexopoulos LG, Rehm M. Skoko J, et al. Among authors: alexopoulos lg. BMC Cell Biol. 2018 Dec 27;19(1):28. doi: 10.1186/s12860-018-0180-1. BMC Cell Biol. 2018. PMID: 30587121 Free PMC article.

8

TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma.

Podder B, Guttà C, Rožanc J, Gerlach E, Feoktistova M, Panayotova-Dimitrova D, Alexopoulos LG, Leverkus M, Rehm M. Podder B, et al. Among authors: alexopoulos lg. Cell Death Differ. 2019 Dec;26(12):2520-2534. doi: 10.1038/s41418-019-0315-8. Epub 2019 Mar 8. Cell Death Differ. 2019. PMID: 30850732 Free PMC article.

9

Detecting and removing inconsistencies between experimental data and signaling network topologies using integer linear programming on interaction graphs.

Melas IN, Samaga R, Alexopoulos LG, Klamt S. Melas IN, et al. Among authors: alexopoulos lg. PLoS Comput Biol. 2013;9(9):e1003204. doi: 10.1371/journal.pcbi.1003204. Epub 2013 Sep 5. PLoS Comput Biol. 2013. PMID: 24039561 Free PMC article.

10

DeepSIBA: chemical structure-based inference of biological alterations using deep learning.

Fotis C, Meimetis N, Sardis A, Alexopoulos LG. Fotis C, et al. Among authors: alexopoulos lg. Mol Omics. 2021 Feb 1;17(1):108-120. doi: 10.1039/d0mo00129e. Epub 2020 Nov 14. Mol Omics. 2021. PMID: 33188379

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