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Synthesis and Biological Evaluation of Cyclobutane-Based β3 Integrin Antagonists: A Novel Approach to Targeting Integrins for Cancer Therapy.
Cancers (Basel). 2023 Aug 8;15(16):4023. doi: 10.3390/cancers15164023.
Cancers (Basel). 2023.
PMID: 37627051
Free PMC article.
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Zhang SM, Rehling D, Jemth AS, Throup A, Landázuri N, Almlöf I, Göttmann M, Valerie NCK, Borhade SR, Wakchaure P, Page BDG, Desroses M, Homan EJ, Scobie M, Rudd SG, Berglund UW, Söderberg-Nauclér C, Stenmark P, Helleday T.
Zhang SM, et al. Among authors: throup a.
Cell Chem Biol. 2021 Dec 16;28(12):1693-1702.e6. doi: 10.1016/j.chembiol.2021.06.001. Epub 2021 Jun 29.
Cell Chem Biol. 2021.
PMID: 34192523
Free article.
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Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Rehling D, Zhang SM, Jemth AS, Koolmeister T, Throup A, Wallner O, Scaletti E, Moriyama T, Nishii R, Davies J, Desroses M, Rudd SG, Scobie M, Homan E, Berglund UW, Yang JJ, Helleday T, Stenmark P.
Rehling D, et al. Among authors: throup a.
J Biol Chem. 2021 Jan-Jun;296:100568. doi: 10.1016/j.jbc.2021.100568. Epub 2021 Mar 19.
J Biol Chem. 2021.
PMID: 33753169
Free PMC article.
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Development of a chemical probe against NUDT15.
Zhang SM, Desroses M, Hagenkort A, Valerie NCK, Rehling D, Carter M, Wallner O, Koolmeister T, Throup A, Jemth AS, Almlöf I, Loseva O, Lundbäck T, Axelsson H, Regmi S, Sarno A, Krämer A, Pudelko L, Bräutigam L, Rasti A, Göttmann M, Wiita E, Kutzner J, Schaller T, Kalderén C, Cázares-Körner A, Page BDG, Krimpenfort R, Eshtad S, Altun M, Rudd SG, Knapp S, Scobie M, Homan EJ, Berglund UW, Stenmark P, Helleday T.
Zhang SM, et al. Among authors: throup a.
Nat Chem Biol. 2020 Oct;16(10):1120-1128. doi: 10.1038/s41589-020-0592-z. Epub 2020 Jul 20.
Nat Chem Biol. 2020.
PMID: 32690945
Free PMC article.
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Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.
Carter M, Jemth AS, Carreras-Puigvert J, Herr P, Martínez Carranza M, Vallin KSA, Throup A, Helleday T, Stenmark P.
Carter M, et al. Among authors: throup a.
Structure. 2018 Feb 6;26(2):295-303.e6. doi: 10.1016/j.str.2018.01.004.
Structure. 2018.
PMID: 29413322
Free article.
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Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.
Llona-Minguez S, Throup A, Steiner E, Lightowler M, Van der Haegen S, Homan E, Eriksson L, Stenmark P, Jenmalm-Jensen A, Helleday T.
Llona-Minguez S, et al. Among authors: throup a.
Org Biomol Chem. 2017 Sep 26;15(37):7758-7764. doi: 10.1039/c7ob02069d.
Org Biomol Chem. 2017.
PMID: 28891572
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Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.
Llona-Minguez S, Häggblad M, Martens U, Throup A, Loseva O, Jemth AS, Lundgren B, Scobie M, Helleday T.
Llona-Minguez S, et al. Among authors: throup a.
Bioorg Med Chem Lett. 2017 Aug 15;27(16):3897-3904. doi: 10.1016/j.bmcl.2017.06.038. Epub 2017 Jun 16.
Bioorg Med Chem Lett. 2017.
PMID: 28687206
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Intramolecular thermal stepwise [2 + 2] cycloadditions: investigation of a stereoselective synthesis of [n.2.0]-bicyclolactones.
Throup A, Patterson LH, Sheldrake HM.
Throup A, et al.
Org Biomol Chem. 2016 Oct 12;14(40):9554-9559. doi: 10.1039/c6ob01661h.
Org Biomol Chem. 2016.
PMID: 27722445
Free PMC article.
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