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Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir.
Preschel HD, Otte RT, Zhuo Y, Ruscoe RE, Burke AJ, Kellerhals R, Horst B, Hennig S, Janssen E, Green AP, Turner NJ, Ruijter E. Preschel HD, et al. Among authors: burke aj. J Org Chem. 2023 Sep 1;88(17):12565-12571. doi: 10.1021/acs.joc.3c01274. Epub 2023 Aug 22. J Org Chem. 2023. PMID: 37607396 Free PMC article.
Enzymes with noncanonical amino acids.
Zhao J, Burke AJ, Green AP. Zhao J, et al. Among authors: burke aj. Curr Opin Chem Biol. 2020 Apr;55:136-144. doi: 10.1016/j.cbpa.2020.01.006. Epub 2020 Mar 9. Curr Opin Chem Biol. 2020. PMID: 32163871 Review.
An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir.
Burke AJ, Birmingham WR, Zhuo Y, Thorpe TW, Zucoloto da Costa B, Crawshaw R, Rowles I, Finnigan JD, Young C, Holgate GM, Muldowney MP, Charnock SJ, Lovelock SL, Turner NJ, Green AP. Burke AJ, et al. J Am Chem Soc. 2022 Mar 9;144(9):3761-3765. doi: 10.1021/jacs.1c11048. Epub 2022 Feb 28. J Am Chem Soc. 2022. PMID: 35224970 Free PMC article.
Strategies for designing biocatalysts with new functions.
Bell EL, Hutton AE, Burke AJ, O'Connell A, Barry A, O'Reilly E, Green AP. Bell EL, et al. Among authors: burke aj. Chem Soc Rev. 2024 Mar 18;53(6):2851-2862. doi: 10.1039/d3cs00972f. Chem Soc Rev. 2024. PMID: 38353665 Free PMC article. Review.
64 results