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The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population.
Medina TS, Murison A, Smith M, Kinker GS, Chakravarthy A, Vitiello GAF, Turpin W, Shen SY, Yau HL, Sarmento OF, Faubion W, Lupien M, Silverberg MS, Arrowsmith CH, De Carvalho DD. Medina TS, et al. Among authors: arrowsmith ch. Front Immunol. 2023 Aug 3;14:1161901. doi: 10.3389/fimmu.2023.1161901. eCollection 2023. Front Immunol. 2023. PMID: 37600767 Free PMC article.
RAS and PP2A activities converge on epigenetic gene regulation.
Aakula A, Sharma M, Tabaro F, Nätkin R, Kamila J, Honkanen H, Schapira M, Arrowsmith C, Nykter M, Westermarck J. Aakula A, et al. Life Sci Alliance. 2023 Mar 1;6(5):e202301928. doi: 10.26508/lsa.202301928. Print 2023 May. Life Sci Alliance. 2023. PMID: 36858798 Free PMC article.
SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1.
Wang Z, Petricca J, Liu M, Zhang S, Chen S, Li M, Besschetnova A, Patalano S, Venkataramani K, Siegfried KR, Macoska JA, Han D, Gao S, Vedadi M, Arrowsmith CH, He HH, Cai C. Wang Z, et al. Among authors: arrowsmith ch. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2220472120. doi: 10.1073/pnas.2220472120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549269 Free PMC article.
Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations.
Alqazzaz MA, Luciani GM, Vu V, Machado RAC, Szewczyk MM, Adamson EC, Cheon S, Li F, Arrowsmith CH, Minden MD, Barsyte-Lovejoy D. Alqazzaz MA, et al. Among authors: arrowsmith ch. Exp Hematol. 2024 Feb;130:104135. doi: 10.1016/j.exphem.2023.11.009. Epub 2023 Dec 10. Exp Hematol. 2024. PMID: 38072134
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells.
Krishnan R, Lapierre M, Gautreau B, Nixon KCJ, El Ghamrasni S, Patel PS, Hao J, Yerlici VT, Guturi KKN, St-Germain J, Mateo F, Saad A, Algouneh A, Earnshaw R, Shili D, Seitova A, Miller J, Khosraviani N, Penn A, Ho B, Sanchez O, Hande MP, Masson JY, Brown GW, Alaoui-Jamali M, Reynolds JJ, Arrowsmith C, Raught B, Pujana MA, Mekhail K, Stewart GS, Hakem A, Hakem R. Krishnan R, et al. Nucleic Acids Res. 2023 Oct 27;51(19):10484-10505. doi: 10.1093/nar/gkad733. Nucleic Acids Res. 2023. PMID: 37697435 Free PMC article.
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor.
Xiong Y, Greschik H, Johansson C, Seifert L, Gamble V, Park KS, Fagan V, Li F, Chau I, Vedadi M, Arrowsmith CH, Brennan P, Fedorov O, Jung M, Farnie G, Liu J, Oppermann U, Schüle R, Jin J. Xiong Y, et al. Among authors: arrowsmith ch. J Med Chem. 2024 Apr 11;67(7):5837-5853. doi: 10.1021/acs.jmedchem.4c00121. Epub 2024 Mar 27. J Med Chem. 2024. PMID: 38533580
Detection of antibodies against the huntingtin protein in human plasma.
Denis HL, Alpaugh M, Alvarez CP, Fenyi A, Barker RA, Chouinard S, Arrowsmith CH, Melki R, Labib R, Harding RJ, Cicchetti F. Denis HL, et al. Among authors: arrowsmith ch. Cell Mol Life Sci. 2023 Jan 18;80(2):45. doi: 10.1007/s00018-023-04687-x. Cell Mol Life Sci. 2023. PMID: 36651994 Free PMC article.
ChemRAP uncovers specific mRNA translation regulation via RNA 5' phospho-methylation.
Ipas H, Gouws EB, Abell NS, Chiou PC, Devanathan SK, Hervé S, Lee S, Mercado M, Reinsborough C, Halabelian L, Arrowsmith CH, Xhemalçe B. Ipas H, et al. Among authors: arrowsmith ch. EMBO Rep. 2024 Mar;25(3):1570-1588. doi: 10.1038/s44319-024-00059-z. Epub 2024 Jan 23. EMBO Rep. 2024. PMID: 38263329 Free PMC article.
372 results