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TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation.
Worboys JD, Vowell KN, Hare RK, Ambrose AR, Bertuzzi M, Conner MA, Patel FP, Zammit WH, Gali-Moya J, Hazime KS, Jones KL, Rey C, Jonjic S, Rovis TL, Tannahill GM, Cruz De Matos GDS, Waight JD, Davis DM. Worboys JD, et al. Among authors: conner ma. Nat Commun. 2023 Aug 18;14(1):5016. doi: 10.1038/s41467-023-40755-3. Nat Commun. 2023. PMID: 37596248 Free PMC article.
Emergence of the CD226 Axis in Cancer Immunotherapy.
Conner M, Hance KW, Yadavilli S, Smothers J, Waight JD. Conner M, et al. Front Immunol. 2022 Jun 24;13:914406. doi: 10.3389/fimmu.2022.914406. eCollection 2022. Front Immunol. 2022. PMID: 35812451 Free PMC article. Review.
Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments.
Yu JW, Bhattacharya S, Yanamandra N, Kilian D, Shi H, Yadavilli S, Katlinskaya Y, Kaczynski H, Conner M, Benson W, Hahn A, Seestaller-Wehr L, Bi M, Vitali NJ, Tsvetkov L, Halsey W, Hughes A, Traini C, Zhou H, Jing J, Lee T, Figueroa DJ, Brett S, Hopson CB, Smothers JF, Hoos A, Srinivasan R. Yu JW, et al. PLoS One. 2018 Nov 2;13(11):e0206223. doi: 10.1371/journal.pone.0206223. eCollection 2018. PLoS One. 2018. PMID: 30388137 Free PMC article.