Molecular Dynamics Simulations of the Mutated Proton-Transferring a-Subunit of E. coli F(o)F(1)-ATP Synthase.
Ivontsin LA, Mashkovtseva EV, Nartsissov YR.
Ivontsin LA, et al.
Int J Mol Sci. 2024 May 9;25(10):5143. doi: 10.3390/ijms25105143.
Int J Mol Sci. 2024.
PMID: 38791189
Free PMC article.
The membrane F(o) factor of ATP synthase is highly sensitive to mutations in the proton half-channel leading to the functional blocking of the entire protein. ...Thus, mutations of conserved polar residues significantly affected hydration levels, leading to drastic changes …
The membrane F(o) factor of ATP synthase is highly sensitive to mutations in the proton half-channel leading to the functional blocki …