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Peripheral nervous system is injured by neutrophil extracellular traps (NETs) elicited by nonstructural (NS) protein-1 from Zika virus.
de Siqueira Santos R, Rochael NC, Mattos TRF, Fallett E Silva MF, Linhares-Lacerda L, de Oliveira LT, Cunha MS, Mohana-Borges R, Gomes TA, Barbosa-Silva MC, Maron-Gutierrez T, Foguel D, Saraiva EM. de Siqueira Santos R, et al. Among authors: mohana borges r. FASEB J. 2023 Sep;37(9):e23126. doi: 10.1096/fj.202201904R. FASEB J. 2023. PMID: 37594040
The immunodominant antibody response to Zika virus NS1 protein is characterized by cross-reactivity to self.
Cavazzoni CB, Bozza VBT, Lucas TCV, Conde L, Maia B, Mesin L, Schiepers A, Ersching J, Neris RLS, Conde JN, Coelho DR, Lima TM, Alvim RGF, Castilho LR, de Paula Neto HA, Mohana-Borges R, Assunção-Miranda I, Nobrega A, Victora GD, Vale AM. Cavazzoni CB, et al. J Exp Med. 2021 Sep 6;218(9):e20210580. doi: 10.1084/jem.20210580. Epub 2021 Jul 22. J Exp Med. 2021. PMID: 34292314 Free PMC article.
76 results