Solid-phase synthesis and screening of macrocyclic nucleotide-hybrid compounds targeted to hepatitis C NS5B.
Smietana M, Johnson RB, Wang QM, Kool ET.
Smietana M, et al.
Chemistry. 2004 Jan 5;10(1):173-81. doi: 10.1002/chem.200305402.
Chemistry. 2004.
PMID: 14695562
This methodology allows a fully automated assembly by means of standard phosphoramidite chemistry and is based on a recently published procedure for the preparation of cyclic oligodinucleotides in the DNA series (M. Smietana, E. T. Kool, Angew. Chem. 2002, 114, 3856 …
This methodology allows a fully automated assembly by means of standard phosphoramidite chemistry and is based on a recently published proce …