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Development of a highly potent and selective degrader of LRRK2.
Hatcher JM, Zwirek M, Sarhan AR, Vatsan PS, Tonelli F, Alessi DR, Davies P, Gray NS. Hatcher JM, et al. Among authors: sarhan ar. Bioorg Med Chem Lett. 2023 Oct 1;94:129449. doi: 10.1016/j.bmcl.2023.129449. Epub 2023 Aug 15. Bioorg Med Chem Lett. 2023. PMID: 37591317
Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR. Purlyte E, et al. Among authors: sarhan ar. EMBO J. 2018 Jan 4;37(1):1-18. doi: 10.15252/embj.201798099. Epub 2017 Dec 6. EMBO J. 2018. PMID: 29212815 Free PMC article.
Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5.
Gilbert AS, Seoane PI, Sephton-Clark P, Bojarczuk A, Hotham R, Giurisato E, Sarhan AR, Hillen A, Velde GV, Gray NS, Alessi DR, Cunningham DL, Tournier C, Johnston SA, May RC. Gilbert AS, et al. Among authors: sarhan ar. Sci Adv. 2017 Aug 16;3(8):e1700898. doi: 10.1126/sciadv.1700898. eCollection 2017 Aug. Sci Adv. 2017. PMID: 28835924 Free PMC article.
Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR. Purlyte E, et al. Among authors: sarhan ar. EMBO J. 2019 Jan 15;38(2):e101237. doi: 10.15252/embj.2018101237. EMBO J. 2019. PMID: 30647193 Free PMC article.
A Biochemical Analysis of Patients with COVID-19 Infection.
Sarhan AR, Hussein TA, Flaih MH, Hussein KR. Sarhan AR, et al. Biochem Res Int. 2021 Oct 22;2021:1383830. doi: 10.1155/2021/1383830. eCollection 2021. Biochem Res Int. 2021. PMID: 34703628 Free PMC article.
16 results