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Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression.
Front Oncol. 2023 Jul 31;13:1225220. doi: 10.3389/fonc.2023.1225220. eCollection 2023.
Front Oncol. 2023.
PMID: 37583931
Free PMC article.
Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells.
Haugrud AB, Zhuang Y, Coppock JD, Miskimins WK.
Haugrud AB, et al.
Breast Cancer Res Treat. 2014 Oct;147(3):539-50. doi: 10.1007/s10549-014-3128-y. Epub 2014 Sep 12.
Breast Cancer Res Treat. 2014.
PMID: 25212175
Free PMC article.
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Mechanisms by which low glucose enhances the cytotoxicity of metformin to cancer cells both in vitro and in vivo.
Zhuang Y, Chan DK, Haugrud AB, Miskimins WK.
Zhuang Y, et al. Among authors: haugrud ab.
PLoS One. 2014 Sep 25;9(9):e108444. doi: 10.1371/journal.pone.0108444. eCollection 2014.
PLoS One. 2014.
PMID: 25254953
Free PMC article.
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Dichloroacetate and Quercetin Prevent Cell Proliferation, Induce Cell Death and Slow Tumor Growth in a Mouse Model of HPV-Positive Head and Neck Cancer.
Zhuang Y, Coppock JD, Haugrud AB, Lee JH, Messerli SM, Miskimins WK.
Zhuang Y, et al. Among authors: haugrud ab.
Cancers (Basel). 2024 Apr 17;16(8):1525. doi: 10.3390/cancers16081525.
Cancers (Basel). 2024.
PMID: 38672607
Free PMC article.
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