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Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance.
Evans N, Grygorash R, Williams P, Kyle A, Kantner T, Pathak R, Sheng X, Simoes F, Makwana H, Resende R, de Juan E, Jenkins A, Morris D, Michelet A, Jewitt F, Rudge F, Camper N, Manin A, McDowell W, Pabst M, Godwin A, Frigerio M, Bird M. Evans N, et al. Among authors: makwana h. Front Pharmacol. 2022 Jun 17;13:764540. doi: 10.3389/fphar.2022.764540. eCollection 2022. Front Pharmacol. 2022. PMID: 35784686 Free PMC article.
Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates.
Pabst M, McDowell W, Manin A, Kyle A, Camper N, De Juan E, Parekh V, Rudge F, Makwana H, Kantner T, Parekh H, Michelet A, Sheng X, Popa G, Tucker C, Khayrzad F, Pollard D, Kozakowska K, Resende R, Jenkins A, Simoes F, Morris D, Williams P, Badescu G, Baker MP, Bird M, Frigerio M, Godwin A. Pabst M, et al. Among authors: makwana h. J Control Release. 2017 May 10;253:160-164. doi: 10.1016/j.jconrel.2017.02.027. Epub 2017 Mar 1. J Control Release. 2017. PMID: 28257988
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