Huang HS - Search Results

1

Mechanistic study of dual-function inhibitors targeting topoisomerase II and Rad51-mediated DNA repair pathway against castration-resistant prostate cancer.

Chiang YC, Leu WJ, Chen YC, Ye PC, Hsu YT, Hsiao YC, Hsu JL, Chan SH, Hsu LC, Huang HS, Guh JH. Chiang YC, et al. Among authors: huang hs. Prostate. 2023 Dec;83(16):1549-1563. doi: 10.1002/pros.24613. Epub 2023 Aug 15. Prostate. 2023. PMID: 37583103

2

Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives.

Lee CC, Huang KF, Lin PY, Huang FC, Chen CL, Chen TC, Guh JH, Lin JJ, Huang HS. Lee CC, et al. Among authors: huang fc, huang kf, huang hs. Eur J Med Chem. 2012 Jan;47(1):323-36. doi: 10.1016/j.ejmech.2011.10.059. Epub 2011 Nov 7. Eur J Med Chem. 2012. PMID: 22100139

3

Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.

Chen CL, Chang DM, Chen TC, Lee CC, Hsieh HH, Huang FC, Huang KF, Guh JH, Lin JJ, Huang HS. Chen CL, et al. Among authors: huang fc, huang kf, huang hs. Eur J Med Chem. 2013 Feb;60:29-41. doi: 10.1016/j.ejmech.2012.11.032. Epub 2012 Nov 29. Eur J Med Chem. 2013. PMID: 23279865

4

Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties.

Lee CC, Chang DM, Huang KF, Chen CL, Chen TC, Lo Y, Guh JH, Huang HS. Lee CC, et al. Among authors: huang kf, huang hs. Bioorg Med Chem. 2013 Nov 15;21(22):7125-33. doi: 10.1016/j.bmc.2013.09.006. Epub 2013 Sep 13. Bioorg Med Chem. 2013. PMID: 24094433

5

A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway.

Hsu JL, Liu SP, Lee CC, Hsu LC, Ho YF, Huang HS, Guh JH. Hsu JL, et al. Among authors: huang hs. Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):979-90. doi: 10.1007/s00210-014-0998-9. Epub 2014 Jul 9. Naunyn Schmiedebergs Arch Pharmacol. 2014. PMID: 25005758

6

Ring fusion strategy for the synthesis of anthra[2,3-d]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents.

Chen CL, Liu FL, Lee CC, Chen TC, Chang WW, Guh JH, Ahmed Ali AA, Chang DM, Huang HS. Chen CL, et al. Among authors: huang hs. Eur J Med Chem. 2014 Nov 24;87:30-8. doi: 10.1016/j.ejmech.2014.09.016. Epub 2014 Sep 6. Eur J Med Chem. 2014. PMID: 25240093

7

Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents.

Lee YR, Chen TC, Lee CC, Chen CL, Ahmed Ali AA, Tikhomirov A, Guh JH, Yu DS, Huang HS. Lee YR, et al. Among authors: huang hs. Eur J Med Chem. 2015 Sep 18;102:661-76. doi: 10.1016/j.ejmech.2015.07.052. Epub 2015 Aug 7. Eur J Med Chem. 2015. PMID: 26344783

8

A Novel Salicylanilide Derivative Induces Autophagy Cell Death in Castration-Resistant Prostate Cancer via ER Stress-Activated PERK Signaling Pathway.

Hsieh CL, Huang HS, Chen KC, Saka T, Chiang CY, Chung LWK, Sung SY. Hsieh CL, et al. Among authors: huang hs. Mol Cancer Ther. 2020 Jan;19(1):101-111. doi: 10.1158/1535-7163.MCT-19-0387. Epub 2019 Sep 17. Mol Cancer Ther. 2020. PMID: 31530650

9

In vivo Pharmacokinetic and Anticancer Studies of HH-N25, a Selective Inhibitor of Topoisomerase I, and Hormonal Signaling for Treating Breast Cancer.

Lawal B, Kuo YC, Sumitra MR, Wu ATH, Huang HS. Lawal B, et al. Among authors: huang hs. J Inflamm Res. 2021 Sep 22;14:4901-4913. doi: 10.2147/JIR.S329401. eCollection 2021. J Inflamm Res. 2021. PMID: 34588796 Free PMC article.

10

Identification of CDK1, PBK, and CHEK1 as an Oncogenic Signature in Glioblastoma: A Bioinformatics Approach to Repurpose Dapagliflozin as a Therapeutic Agent.

Chinyama HA, Wei L, Mokgautsi N, Lawal B, Wu ATH, Huang HS. Chinyama HA, et al. Among authors: huang hs. Int J Mol Sci. 2023 Nov 16;24(22):16396. doi: 10.3390/ijms242216396. Int J Mol Sci. 2023. PMID: 38003585 Free PMC article.

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