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Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing.
Wimberger S, Akrap N, Firth M, Brengdahl J, Engberg S, Schwinn MK, Slater MR, Lundin A, Hsieh PP, Li S, Cerboni S, Sumner J, Bestas B, Schiffthaler B, Magnusson B, Di Castro S, Iyer P, Bohlooly-Y M, Machleidt T, Rees S, Engkvist O, Norris T, Cadogan EB, Forment JV, Šviković S, Akcakaya P, Taheri-Ghahfarokhi A, Maresca M. Wimberger S, et al. Among authors: bestas b. Nat Commun. 2023 Aug 14;14(1):4761. doi: 10.1038/s41467-023-40344-4. Nat Commun. 2023. PMID: 37580318 Free PMC article.
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo.
Bazaz S, Lehto T, Tops R, Gissberg O, Gupta D, Bestas B, Bost J, Wiklander OPB, Sork H, Zaghloul EM, Mamand DR, Hällbrink M, Sillard R, Saher O, Ezzat K, Smith CIE, Andaloussi SE, Lehto T. Bazaz S, et al. Among authors: bestas b. Biomedicines. 2021 Aug 19;9(8):1046. doi: 10.3390/biomedicines9081046. Biomedicines. 2021. PMID: 34440250 Free PMC article.
Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency.
Sork H, Nordin JZ, Turunen JJ, Wiklander OP, Bestas B, Zaghloul EM, Margus H, Padari K, Duru AD, Corso G, Bost J, Vader P, Pooga M, Smith CE, Wood MJ, Schiffelers RM, Hällbrink M, Andaloussi SE. Sork H, et al. Among authors: bestas b. Mol Ther Nucleic Acids. 2016 Mar 8;5(3):e290. doi: 10.1038/mtna.2016.8. Mol Ther Nucleic Acids. 2016. PMID: 27111416 Free PMC article.
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
Bestas B, Moreno PM, Blomberg KE, Mohammad DK, Saleh AF, Sutlu T, Nordin JZ, Guterstam P, Gustafsson MO, Kharazi S, Piątosa B, Roberts TC, Behlke MA, Wood MJ, Gait MJ, Lundin KE, El Andaloussi S, Månsson R, Berglöf A, Wengel J, Smith CI. Bestas B, et al. J Clin Invest. 2014 Sep;124(9):4067-81. doi: 10.1172/JCI76175. Epub 2014 Aug 8. J Clin Invest. 2014. PMID: 25105368 Free PMC article.
Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes.
Zabulica M, Srinivasan RC, Akcakaya P, Allegri G, Bestas B, Firth M, Hammarstedt C, Jakobsson T, Jakobsson T, Ellis E, Jorns C, Makris G, Scherer T, Rimann N, van Zuydam NR, Gramignoli R, Forslöw A, Engberg S, Maresca M, Rooyackers O, Thöny B, Häberle J, Rosen B, Strom SC. Zabulica M, et al. Among authors: bestas b. Mol Ther. 2021 May 5;29(5):1903-1917. doi: 10.1016/j.ymthe.2021.01.024. Epub 2021 Jan 21. Mol Ther. 2021. PMID: 33484963 Free PMC article.
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