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Estradiol mitigates stress-induced cardiac injury and inflammation by downregulating ADAM17 via the GPER-1/PI3K signaling pathway.
Cell Mol Life Sci. 2023 Aug 12;80(9):246. doi: 10.1007/s00018-023-04886-6.
Cell Mol Life Sci. 2023.
PMID: 37572114
Free PMC article.
Estrogen downregulates CD73/adenosine axis hyperactivity via adaptive modulation PI3K/Akt signaling to prevent myocarditis and arrhythmias during chronic catecholamines stress.
Ndzie Noah ML, Adzika GK, Mprah R, Adekunle AO, Koda S, Adu-Amankwaah J, Xu Y, Kanwore K, Wowui PI, Sun H.
Ndzie Noah ML, et al. Among authors: wowui pi.
Cell Commun Signal. 2023 Feb 23;21(1):41. doi: 10.1186/s12964-023-01052-0.
Cell Commun Signal. 2023.
PMID: 36823590
Free PMC article.
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Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension.
Mprah R, Ma Y, Adzika GK, Ndzie Noah ML, Adekunle AO, Duah M, Adu-Amankwaah J, Wowui PI, Okwuma JD, Qiao W, Wang C.
Mprah R, et al. Among authors: wowui pi.
Clin Exp Pharmacol Physiol. 2022 May;49(5):558-566. doi: 10.1111/1440-1681.13633. Epub 2022 Feb 23.
Clin Exp Pharmacol Physiol. 2022.
PMID: 35133684
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Occlusion preconditioned mice are resilient to hypobaric hypoxia-induced myocarditis and arrhythmias due to enhanced immunomodulation, metabolic homeostasis, and antioxidants defense.
Adzika GK, Mprah R, Rizvi R, Adekunle AO, Ndzie Noah ML, Wowui PI, Adzraku SY, Adu-Amankwaah J, Wang F, Lin Y, Fu L, Liu X, Xiang J, Sun H.
Adzika GK, et al. Among authors: wowui pi.
Front Immunol. 2023 Feb 15;14:1124649. doi: 10.3389/fimmu.2023.1124649. eCollection 2023.
Front Immunol. 2023.
PMID: 36875113
Free PMC article.
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Glutaminolysis: A Driver of Vascular and Cardiac Remodeling in Pulmonary Arterial Hypertension.
Mprah R, Adzika GK, Gyasi YI, Ndzie Noah ML, Adu-Amankwaah J, Adekunle AO, Duah M, Wowui PI, Weili Q.
Mprah R, et al. Among authors: wowui pi.
Front Cardiovasc Med. 2021 Apr 28;8:667446. doi: 10.3389/fcvm.2021.667446. eCollection 2021.
Front Cardiovasc Med. 2021.
PMID: 33996951
Free PMC article.
Review.
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Estradiol contributes to sex differences in resilience to sepsis-induced metabolic dysregulation and dysfunction in the heart via GPER-1-mediated PPARδ/NLRP3 signaling.
Adu-Amankwaah J, Adekunle AO, Tang Z, Bushi A, Tan R, Fu L, Gong Z, Ma Z, Mprah R, Ndzie Noah ML, Wowui PI, Ong'achwa Machuki J, Pan X, Li T, Sun H.
Adu-Amankwaah J, et al. Among authors: wowui pi.
Metabolism. 2024 May 16;156:155934. doi: 10.1016/j.metabol.2024.155934. Online ahead of print.
Metabolism. 2024.
PMID: 38762141
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CD73/adenosine axis exerts cardioprotection against hypobaric hypoxia-induced metabolic shift and myocarditis in a sex-dependent manner.
Ndzie Noah ML, Mprah R, Wowui PI, Adekunle AO, Adu-Amankwaah J, Tan R, Gong Z, Li T, Fu L, Machuki JO, Zhang S, Sun H.
Ndzie Noah ML, et al. Among authors: wowui pi.
Cell Commun Signal. 2024 Mar 7;22(1):166. doi: 10.1186/s12964-024-01535-8.
Cell Commun Signal. 2024.
PMID: 38454449
Free PMC article.
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