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AtomNet-Aided OTUD7B Inhibitor Discovery and Validation.
Chen J, Bolhuis DL, Laggner C, Kong D, Yu L, Wang X, Emanuele MJ, Brown NG, Liu P. Chen J, et al. Among authors: emanuele mj. Cancers (Basel). 2023 Jan 14;15(2):517. doi: 10.3390/cancers15020517. Cancers (Basel). 2023. PMID: 36672466 Free PMC article.
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins.
Lu X, Chandravanshi M, Sabbasani VR, Gaikwad S, Hughitt VK, Gyabaah-Kessie N, Scroggins BT, Das S, Myint W, Clapp ME, Schwieters CD, Dyba MA, Bolhuis DL, Koscielniak JW, Andresson T, Emanuele MJ, Brown NG, Matsuo H, Chari R, Citrin DE, Mock BA, Swenson RE, Walters KJ. Lu X, et al. Among authors: emanuele mj. Nat Commun. 2024 Mar 20;15(1):2485. doi: 10.1038/s41467-024-46644-7. Nat Commun. 2024. PMID: 38509117 Free PMC article.
APC/C and SCFcyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry.
Choudhury R, Bonacci T, Arceci A, Lahiri D, Mills CA, Kernan JL, Branigan TB, DeCaprio JA, Burke DJ, Emanuele MJ. Choudhury R, et al. Among authors: emanuele mj. Cell Rep. 2024 Mar 26;43(3):113974. doi: 10.1016/j.celrep.2024.113974. Epub 2024 Mar 7. Cell Rep. 2024. PMID: 38457340 Free PMC article. No abstract available.
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Bodrug T, Welsh KA, Bolhuis DL, Paulаkonis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG. Bodrug T, et al. Among authors: emanuele mj. Nat Struct Mol Biol. 2023 Nov;30(11):1663-1674. doi: 10.1038/s41594-023-01105-5. Epub 2023 Sep 21. Nat Struct Mol Biol. 2023. PMID: 37735619 Free PMC article.
47 results