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Enhancing the Drug-Like Profile of a Potent Peptide PACE4 Inhibitor by the Formation of a Host-Guest Inclusion Complex with β-Cyclodextrin.
Mol Pharm. 2023 Sep 4;20(9):4559-4573. doi: 10.1021/acs.molpharmaceut.3c00261. Epub 2023 Aug 9.
Mol Pharm. 2023.
PMID: 37555521
Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin.
Lewandowska-Goch MA, Kwiatkowska A, Łepek T, Ly K, Navals P, Gagnon H, Dory YL, Prahl A, Day R.
Lewandowska-Goch MA, et al. Among authors: navals p.
ACS Med Chem Lett. 2021 Feb 5;12(3):365-372. doi: 10.1021/acsmedchemlett.0c00386. eCollection 2021 Mar 11.
ACS Med Chem Lett. 2021.
PMID: 33738063
Free PMC article.
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Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue.
Dianati V, Navals P, Couture F, Desjardins R, Dame A, Kwiatkowska A, Day R, Dory YL.
Dianati V, et al. Among authors: navals p.
J Med Chem. 2018 Dec 27;61(24):11250-11260. doi: 10.1021/acs.jmedchem.8b01381. Epub 2018 Dec 13.
J Med Chem. 2018.
PMID: 30501188
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Conformational Modulation of Tissue Transglutaminase via Active Site Thiol Alkylating Agents: Size Does Not Matter.
Navals P, Rangaswamy AMM, Kasyanchyk P, Berezovski MV, Keillor JW.
Navals P, et al.
Biomolecules. 2024 Apr 19;14(4):496. doi: 10.3390/biom14040496.
Biomolecules. 2024.
PMID: 38672511
Free PMC article.
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Transcriptomics Studies Reveal Functions of Transglutaminase 2 in Breast Cancer Cells Using Membrane Permeable and Impermeable Inhibitors.
Ancona P, Trentini A, Terrazzan A, Grassilli S, Navals P, Gates EWJ, Rosta V, Cervellati C, Bergamini CM, Pignatelli A, Keillor JW, Taccioli C, Bianchi N.
Ancona P, et al. Among authors: navals p.
J Mol Biol. 2024 May 15;436(10):168569. doi: 10.1016/j.jmb.2024.168569. Epub 2024 Apr 10.
J Mol Biol. 2024.
PMID: 38604527
Free article.
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Cell-Impermeable Inhibitors Confirm That Intracellular Human Transglutaminase 2 Is Responsible for the Transglutaminase-Associated Cancer Phenotype.
Gates EWJ, Calvert ND, Cundy NJ, Brugnoli F, Navals P, Kirby A, Bianchi N, Adhikary G, Shuhendler AJ, Eckert RL, Keillor JW.
Gates EWJ, et al. Among authors: navals p.
Int J Mol Sci. 2023 Aug 8;24(16):12546. doi: 10.3390/ijms241612546.
Int J Mol Sci. 2023.
PMID: 37628729
Free PMC article.
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Facial Gender-Affirming Surgery: Frontal Bossing Surgical Techniques, Outcomes and Safety.
Bonapace-Potvin M, Pepin M, Navals P, Medor MC, Lorange E, Bensimon É.
Bonapace-Potvin M, et al. Among authors: navals p.
Aesthetic Plast Surg. 2023 Aug;47(4):1353-1361. doi: 10.1007/s00266-022-03180-3. Epub 2022 Nov 22.
Aesthetic Plast Surg. 2023.
PMID: 36414725
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Structure-activity relationships of hydrophobic alkyl acrylamides as tissue transglutaminase inhibitors.
Rangaswamy AMM, Navals P, Gates EWJ, Shad S, Watt SKI, Keillor JW.
Rangaswamy AMM, et al. Among authors: navals p.
RSC Med Chem. 2022 Jan 26;13(4):413-428. doi: 10.1039/d1md00382h. eCollection 2022 Apr 20.
RSC Med Chem. 2022.
PMID: 35647547
Free PMC article.
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