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Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.
Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL. Rawat V, et al. Among authors: denicola gm. bioRxiv [Preprint]. 2023 Jul 28:2023.07.26.550731. doi: 10.1101/2023.07.26.550731. bioRxiv. 2023. PMID: 37546939 Free PMC article. Preprint.
Making sense of reAKTive oxygen species.
DeNicola GM, Harris IS. DeNicola GM, et al. Cell Death Differ. 2016 Aug;23(8):1269-70. doi: 10.1038/cdd.2016.57. Epub 2016 Jun 17. Cell Death Differ. 2016. PMID: 27315299 Free PMC article. No abstract available.
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.
Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS. Harris IS, et al. Among authors: denicola gm. Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21. Cell Metab. 2019. PMID: 30799286 Free PMC article.
PHGDH supports liver ceramide synthesis and sustains lipid homeostasis.
Kang YP, Falzone A, Liu M, González-Sánchez P, Choi BH, Coloff JL, Saller JJ, Karreth FA, DeNicola GM. Kang YP, et al. Among authors: denicola gm. Cancer Metab. 2020 Jun 15;8:6. doi: 10.1186/s40170-020-00212-x. eCollection 2020. Cancer Metab. 2020. PMID: 32549981 Free PMC article.
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis.
Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, Harris IS, DeNicola GM. Kang YP, et al. Among authors: denicola gm. Cell Metab. 2021 Jan 5;33(1):174-189.e7. doi: 10.1016/j.cmet.2020.12.007. Epub 2020 Dec 22. Cell Metab. 2021. PMID: 33357455 Free PMC article.
The microbiome(s) and cancer: know thy neighbor(s).
González-Sánchez P, DeNicola GM. González-Sánchez P, et al. Among authors: denicola gm. J Pathol. 2021 Jul;254(4):332-343. doi: 10.1002/path.5661. Epub 2021 Apr 1. J Pathol. 2021. PMID: 33723873 Review.
Glutathione supports lipid abundance in vivo.
Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Duncan R, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith Z, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS. Asantewaa G, et al. Among authors: denicola gm. bioRxiv [Preprint]. 2023 Feb 11:2023.02.10.524960. doi: 10.1101/2023.02.10.524960. bioRxiv. 2023. PMID: 36798186 Free PMC article. Preprint.
ASCT2 is the primary serine transporter in cancer cells.
Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. Conger KO, et al. Among authors: denicola gm. bioRxiv [Preprint]. 2023 Oct 11:2023.10.09.561530. doi: 10.1101/2023.10.09.561530. bioRxiv. 2023. PMID: 37873453 Free PMC article. Preprint.
71 results