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PDGF receptors are activated in human epiretinal membranes.
Cui J, Lei H, Samad A, Basavanthappa S, Maberley D, Matsubara J, Kazlauskas A. Cui J, et al. Among authors: lei h. Exp Eye Res. 2009 Mar;88(3):438-44. doi: 10.1016/j.exer.2008.10.020. Epub 2008 Nov 8. Exp Eye Res. 2009. PMID: 19032953 Free PMC article.
Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells.
Lei H, Kazlauskas A. Lei H, et al. J Biol Chem. 2009 Mar 6;284(10):6329-36. doi: 10.1074/jbc.M808426200. Epub 2009 Jan 6. J Biol Chem. 2009. PMID: 19126548 Free PMC article.
Although platelet-derived growth factors (PDGFs) are present in the vitreous, vitreal growth factors outside of the PDGF family activated the PDGF alpha receptor (PDGFRalpha) and promoted disease progression in a rabbit model of proliferative vitreoretinopathy (H. Lei …
Although platelet-derived growth factors (PDGFs) are present in the vitreous, vitreal growth factors outside of the PDGF family activated th …
Growth factors outside the PDGF family drive experimental PVR.
Lei H, Velez G, Hovland P, Hirose T, Gilbertson D, Kazlauskas A. Lei H, et al. Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3394-403. doi: 10.1167/iovs.08-3042. Epub 2009 Mar 25. Invest Ophthalmol Vis Sci. 2009. PMID: 19324843 Free PMC article.
3,642 results