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Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity.
Dichiara M, Ambrosio FA, Lee SM, Ruiz-Cantero MC, Lombino J, Coricello A, Costa G, Shah D, Costanzo G, Pasquinucci L, Son KN, Cosentino G, González-Cano R, Marrazzo A, Aakalu VK, Cobos EJ, Alcaro S, Amata E. Dichiara M, et al. Among authors: alcaro s. J Med Chem. 2023 Aug 24;66(16):11447-11463. doi: 10.1021/acs.jmedchem.3c00959. Epub 2023 Aug 3. J Med Chem. 2023. PMID: 37535861 Free PMC article.
Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.
Cappelli A, Gallelli A, Manini M, Anzini M, Mennuni L, Makovec F, Menziani MC, Alcaro S, Ortuso F, Vomero S. Cappelli A, et al. Among authors: alcaro s. J Med Chem. 2005 May 19;48(10):3564-75. doi: 10.1021/jm0493461. J Med Chem. 2005. PMID: 15887964
Chalcones: a valid scaffold for monoamine oxidases inhibitors.
Chimenti F, Fioravanti R, Bolasco A, Chimenti P, Secci D, Rossi F, Yáñez M, Orallo F, Ortuso F, Alcaro S. Chimenti F, et al. Among authors: alcaro s. J Med Chem. 2009 May 14;52(9):2818-24. doi: 10.1021/jm801590u. J Med Chem. 2009. PMID: 19378991
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.
Chimenti F, Secci D, Bolasco A, Chimenti P, Granese A, Carradori S, Maccioni E, Cardia MC, Yáñez M, Orallo F, Alcaro S, Ortuso F, Cirilli R, Ferretti R, Distinto S, Kirchmair J, Langer T. Chimenti F, et al. Among authors: alcaro s. Bioorg Med Chem. 2010 Jul 15;18(14):5063-70. doi: 10.1016/j.bmc.2010.05.070. Epub 2010 Jun 1. Bioorg Med Chem. 2010. PMID: 20579890
263 results