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Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities.
Gomaa HAM, Shaker ME, Alzarea SI, Hendawy OM, Mohamed FAM, Gouda AM, Ali AT, Morcoss MM, Abdelrahman MH, Trembleau L, Youssif BGM. Gomaa HAM, et al. Among authors: alzarea si. Bioorg Chem. 2022 Mar;120:105616. doi: 10.1016/j.bioorg.2022.105616. Epub 2022 Jan 19. Bioorg Chem. 2022. PMID: 35078049
New Cytotoxic Natural Products from the Red Sea Sponge Stylissa carteri.
Abdelhameed RFA, Habib ES, Eltahawy NA, Hassanean HA, Ibrahim AK, Mohammed AF, Fayez S, Hayallah AM, Yamada K, Behery FA, Al-Sanea MM, Alzarea SI, Bringmann G, Ahmed SA, Abdelmohsen UR. Abdelhameed RFA, et al. Among authors: alzarea si. Mar Drugs. 2020 May 3;18(5):241. doi: 10.3390/md18050241. Mar Drugs. 2020. PMID: 32375235 Free PMC article.
Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights.
Al-Sanea MM, Elkamhawy A, Paik S, Lee K, El Kerdawy AM, Syed Nasir Abbas B, Joo Roh E, Eldehna WM, Elshemy HAH, Bakr RB, Ali Farahat I, Alzarea AI, Alzarea SI, Alharbi KS, Abdelgawad MA. Al-Sanea MM, et al. Among authors: alzarea si, alzarea ai. Bioorg Med Chem. 2020 Jul 1;28(13):115525. doi: 10.1016/j.bmc.2020.115525. Epub 2020 Apr 25. Bioorg Med Chem. 2020. PMID: 32371117
138 results