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Oligosymptomatic long-term carriers of SARS-CoV-2 display impaired innate resistance but increased high-affinity anti-spike antibodies.
Montes-Cobos E, Bastos VC, Monteiro C, de Freitas JCR, Fernandes HDP, Constancio CS, Rodrigues DAS, Gama AMDS, Vidal VM, Alves LS, Zalcberg-Renault L, de Lira GS, Ota VA, Caloba C, Conde L, Leitão IC, Tanuri A, Ferreira ODC, Pereira RM, Vale AM, Castiñeiras TM, Kaiserlian D, Echevarria-Lima J, Bozza MT. Montes-Cobos E, et al. Among authors: pereira rm. iScience. 2023 Jun 28;26(7):107219. doi: 10.1016/j.isci.2023.107219. eCollection 2023 Jul 21. iScience. 2023. PMID: 37529320 Free PMC article.
Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation.
Fernandez PL, Dutra FF, Alves L, Figueiredo RT, Mourão-Sa D, Fortes GB, Bergstrand S, Lönn D, Cevallos RR, Pereira RMS, Lopes UG, Travassos LH, Paiva CN, Bozza MT. Fernandez PL, et al. J Biol Chem. 2010 Oct 22;285(43):32844-32851. doi: 10.1074/jbc.M110.146076. Epub 2010 Aug 20. J Biol Chem. 2010. PMID: 20729208 Free PMC article.
795 results