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Oral edaravone demonstrated a favorable safety profile in patients with amyotrophic lateral sclerosis after 48 weeks of treatment.
Genge A, Pattee GL, Sobue G, Aoki M, Yoshino H, Couratier P, Lunetta C, Petri S, Selness D, Bidani S, Hirai M, Sakata T, Salah A, Apple S, Wamil A, Kalin A, Jackson CE. Genge A, et al. Among authors: apple s. Muscle Nerve. 2023 Feb;67(2):124-129. doi: 10.1002/mus.27768. Epub 2022 Dec 28. Muscle Nerve. 2023. PMID: 36504406 Free PMC article. Clinical Trial.
Evidence for generalizability of edaravone efficacy using a novel machine learning risk-based subgroup analysis tool.
Brooks BR, Pioro EP, Beaulieu D, Taylor AA, Schactman M, Keymer M, Agnese W, Perdrizet J, Apple S, Ennist DL. Brooks BR, et al. Among authors: apple s. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Feb;23(1-2):49-57. doi: 10.1080/21678421.2021.1927102. Epub 2021 Jul 10. Amyotroph Lateral Scler Frontotemporal Degener. 2022. PMID: 34251911
Post-hoc analyses of the edaravone clinical trials Study 16 and Study 19: a step toward more efficient clinical trial designs in amyotrophic lateral sclerosis.
Palumbo JM, Hubble J, Apple S, Takei K, Tsuda K, Liu S, Zhang J, Agnese W. Palumbo JM, et al. Among authors: apple s. Amyotroph Lateral Scler Frontotemporal Degener. 2019 Aug;20(5-6):421-431. doi: 10.1080/21678421.2019.1599955. Epub 2019 Apr 13. Amyotroph Lateral Scler Frontotemporal Degener. 2019. PMID: 30982356
Clinical staging in amyotrophic lateral sclerosis: analysis of Edaravone Study 19.
Al-Chalabi A, Chiò A, Merrill C, Oster G, Bornheimer R, Agnese W, Apple S. Al-Chalabi A, et al. Among authors: apple s. J Neurol Neurosurg Psychiatry. 2021 Feb;92(2):165-171. doi: 10.1136/jnnp-2020-323271. Epub 2020 Oct 27. J Neurol Neurosurg Psychiatry. 2021. PMID: 33109706 Free PMC article. Clinical Trial.
116 results