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Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1.
Osum SH, Oribamise EI, Corbière SMAS, Taisto M, Jubenville T, Coutts A, Kirstein MN, Fisher J, Moertel C, Du M, Bedwell D, Largaespada DA, Watson AL. Osum SH, et al. Among authors: watson al. Mol Ther Nucleic Acids. 2023 Jun 26;33:227-239. doi: 10.1016/j.omtn.2023.06.018. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37520682 Free PMC article.
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1.
Isakson SH, Rizzardi AE, Coutts AW, Carlson DF, Kirstein MN, Fisher J, Vitte J, Williams KB, Pluhar GE, Dahiya S, Widemann BC, Dombi E, Rizvi T, Ratner N, Messiaen L, Stemmer-Rachamimov AO, Fahrenkrug SC, Gutmann DH, Giovannini M, Moertel CL, Largaespada DA, Watson AL. Isakson SH, et al. Among authors: watson al. Commun Biol. 2018 Oct 2;1:158. doi: 10.1038/s42003-018-0163-y. eCollection 2018. Commun Biol. 2018. PMID: 30302402 Free PMC article.
Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo.
Osum SH, Coutts AW, Duerre DJ, Tschida BR, Kirstein MN, Fisher J, Bell WR, Delpuech O, Smith PD, Widemann BC, Moertel CL, Largaespada DA, Watson AL. Osum SH, et al. Among authors: watson al. Neurooncol Adv. 2021 Feb 10;3(1):vdab020. doi: 10.1093/noajnl/vdab020. eCollection 2021 Jan-Dec. Neurooncol Adv. 2021. PMID: 33978635 Free PMC article.
PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.
Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA. Keng VW, et al. Among authors: watson al. Cancer Res. 2012 Jul 1;72(13):3405-13. doi: 10.1158/0008-5472.CAN-11-4092. Epub 2012 Jun 14. Cancer Res. 2012. PMID: 22700876 Free PMC article.
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.
Rahrmann EP, Watson AL, Keng VW, Choi K, Moriarity BS, Beckmann DA, Wolf NK, Sarver A, Collins MH, Moertel CL, Wallace MR, Gel B, Serra E, Ratner N, Largaespada DA. Rahrmann EP, et al. Among authors: watson al. Nat Genet. 2013 Jul;45(7):756-66. doi: 10.1038/ng.2641. Epub 2013 May 19. Nat Genet. 2013. PMID: 23685747 Free PMC article.
Engineered Swine Models of Cancer.
Watson AL, Carlson DF, Largaespada DA, Hackett PB, Fahrenkrug SC. Watson AL, et al. Front Genet. 2016 May 9;7:78. doi: 10.3389/fgene.2016.00078. eCollection 2016. Front Genet. 2016. PMID: 27242889 Free PMC article. Review.
93 results