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Rapid isothermal point-of-care test for screening of SARS-CoV-2 (COVID-19).
Zingg JM, Yang YP, Seely S, Joshi P, Roshid MHO, Iribarren Latasa F, O'Connor G, Alfaro J, Riquelme E, Bernales S, Dikici E, Deo S, Daunert S. Zingg JM, et al. Among authors: bernales s. Asp Mol Med. 2023;1:100002. doi: 10.1016/j.amolm.2023.100002. Epub 2023 Jan 31. Asp Mol Med. 2023. PMID: 37519861 Free PMC article. Review.
Suppression of Ah Receptor (AhR) increases the aggressiveness of TNBC cells and 11-Cl-BBQ-activated AhR inhibits their growth.
Elson DJ, Nguyen BD, Korjeff NA, Wilferd SF, Puig-Sanvicens V, Sang Jang H, Bernales S, Chakravarty S, Belmar S, Ureta G, Finlay D, Plaisier CL, Kolluri SK. Elson DJ, et al. Among authors: bernales s. Biochem Pharmacol. 2023 Sep;215:115706. doi: 10.1016/j.bcp.2023.115706. Epub 2023 Jul 26. Biochem Pharmacol. 2023. PMID: 37506922
Necroptosis inhibition counteracts neurodegeneration, memory decline, and key hallmarks of aging, promoting brain rejuvenation.
Arrázola MS, Lira M, Véliz-Valverde F, Quiroz G, Iqbal S, Eaton SL, Lamont DJ, Huerta H, Ureta G, Bernales S, Cárdenas JC, Cerpa W, Wishart TM, Court FA. Arrázola MS, et al. Among authors: bernales s. Aging Cell. 2023 May;22(5):e13814. doi: 10.1111/acel.13814. Epub 2023 Mar 27. Aging Cell. 2023. PMID: 36973898 Free PMC article.
Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline.
Elson DJ, Nguyen BD, Bernales S, Chakravarty S, Jang HS, Korjeff NA, Zhang Y, Wilferd SF, Castro DJ, Plaisier CL, Finlay D, Oshima RG, Kolluri SK. Elson DJ, et al. Among authors: bernales s. ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042. doi: 10.1021/acsptsci.2c00253. eCollection 2023 Jul 14. ACS Pharmacol Transl Sci. 2023. PMID: 37470014
Discovery of MDV6058 (PF-06952229), a selective and potent TGFβR1 inhibitor: Design, synthesis and optimization.
Pujala B, Ramachandran SA, Sonawane M, Kamble MM, Panpatil D, Adhikari S, Soni S, Subbareddy V, Shinde BU, Nayak AK, Bansal C, Gupta A, Mukherjee K, Agarwal AK, Guerrero J, Herrera FJ, Bernales S, Guha M, Chakravarty S, Pham SM, Rai R. Pujala B, et al. Among authors: bernales s. Bioorg Med Chem Lett. 2022 Nov 1;75:128979. doi: 10.1016/j.bmcl.2022.128979. Epub 2022 Sep 8. Bioorg Med Chem Lett. 2022. PMID: 36089110
Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors.
Ramachandran SA, Jadhavar PS, Miglani SK, Singh MP, Kalane DP, Agarwal AK, Sathe BD, Mukherjee K, Gupta A, Haldar S, Raja M, Singh S, Pham SM, Chakravarty S, Quinn K, Belmar S, Alfaro IE, Higgs C, Bernales S, Herrera FJ, Rai R. Ramachandran SA, et al. Among authors: bernales s. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160. doi: 10.1016/j.bmcl.2017.03.064. Epub 2017 Mar 24. Bioorg Med Chem Lett. 2017. PMID: 28377059
Dual Inhibition of Bruton's Tyrosine Kinase and Phosphoinositide-3-Kinase p110δ as a Therapeutic Approach to Treat Non-Hodgkin's B Cell Malignancies.
Alfaro J, Pérez de Arce F, Belmar S, Fuentealba G, Avila P, Ureta G, Flores C, Acuña C, Delgado L, Gaete D, Pujala B, Barde A, Nayak AK, Upendra TVR, Patel D, Chauhan S, Sharma VK, Kanno S, Almirez RG, Hung DT, Chakravarty S, Rai R, Bernales S, Quinn KP, Pham SM, McCullagh E. Alfaro J, et al. Among authors: bernales s. J Pharmacol Exp Ther. 2017 May;361(2):312-321. doi: 10.1124/jpet.116.238022. Epub 2017 Mar 15. J Pharmacol Exp Ther. 2017. PMID: 28298527
33 results