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Unacylated ghrelin normalizes skeletal muscle oxidative stress and prevents muscle catabolism by enhancing tissue mitophagy in experimental chronic kidney disease.
Gortan Cappellari G, Semolic A, Ruozi G, Vinci P, Guarnieri G, Bortolotti F, Barbetta D, Zanetti M, Giacca M, Barazzoni R. Gortan Cappellari G, et al. FASEB J. 2017 Dec;31(12):5159-5171. doi: 10.1096/fj.201700126R. Epub 2017 Aug 4. FASEB J. 2017. PMID: 28778977 Free article.
Here we show in a 5/6 nephrectomy (Nx) CKD rat model that 4 d s.c. UnAG administration (200 g twice a day) normalizes CKD-induced loss of gastrocnemius muscle mass and a cluster of high tissue mitochondrial reactive oxygen species generation, high proinflammatory cytokines …
Here we show in a 5/6 nephrectomy (Nx) CKD rat model that 4 d s.c. UnAG administration (200 g twice a day) normalizes CKD-induced los …
Acylated ghrelin treatment normalizes skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rat chronic heart failure.
Barazzoni R, Gortan Cappellari G, Palus S, Vinci P, Ruozi G, Zanetti M, Semolic A, Ebner N, von Haehling S, Sinagra G, Giacca M, Springer J. Barazzoni R, et al. Among authors: gortan cappellari g. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):991-998. doi: 10.1002/jcsm.12254. Epub 2017 Nov 3. J Cachexia Sarcopenia Muscle. 2017. PMID: 29098797 Free PMC article.
n-3 PUFA dietary lipid replacement normalizes muscle mitochondrial function and oxidative stress through enhanced tissue mitophagy and protects from muscle wasting in experimental kidney disease.
Gortan Cappellari G, Semolic A, Ruozi G, Barbetta D, Bortolotti F, Vinci P, Zanetti M, Mak RH, Garibotto G, Giacca M, Barazzoni R. Gortan Cappellari G, et al. Metabolism. 2022 Aug;133:155242. doi: 10.1016/j.metabol.2022.155242. Epub 2022 Jun 21. Metabolism. 2022. PMID: 35750236 Free article.
Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)-nuclear factor-κB (NFκB) activation in rat muscle, in the absence of mitochondrial dysfunction.
Barazzoni R, Zanetti M, Gortan Cappellari G, Semolic A, Boschelle M, Codarin E, Pirulli A, Cattin L, Guarnieri G. Barazzoni R, et al. Among authors: gortan cappellari g. Diabetologia. 2012 Mar;55(3):773-82. doi: 10.1007/s00125-011-2396-x. Epub 2011 Dec 13. Diabetologia. 2012. PMID: 22159911
Ghrelin and muscle metabolism in chronic uremia.
Barazzoni R, Gortan Cappellari G, Zanetti M, Guarnieri G. Barazzoni R, et al. Among authors: gortan cappellari g. J Ren Nutr. 2012 Jan;22(1):171-5. doi: 10.1053/j.jrn.2011.10.017. J Ren Nutr. 2012. PMID: 22200437 Review.
Unacylated Ghrelin Reduces Skeletal Muscle Reactive Oxygen Species Generation and Inflammation and Prevents High-Fat Diet-Induced Hyperglycemia and Whole-Body Insulin Resistance in Rodents.
Gortan Cappellari G, Zanetti M, Semolic A, Vinci P, Ruozi G, Falcione A, Filigheddu N, Guarnieri G, Graziani A, Giacca M, Barazzoni R. Gortan Cappellari G, et al. Diabetes. 2016 Apr;65(4):874-86. doi: 10.2337/db15-1019. Epub 2016 Jan 28. Diabetes. 2016. PMID: 26822085 Free article.
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