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Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.
Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A, Szoleczky P, Gerö D, Yanagi K, Törö G, López-García I, Myrianthopoulos V, Mikros E, Zatarain JR, Chao C, Papapetropoulos A, Hellmich MR, Szabo C. Druzhyna N, et al. Among authors: modis k. Pharmacol Res. 2016 Nov;113(Pt A):18-37. doi: 10.1016/j.phrs.2016.08.016. Epub 2016 Aug 10. Pharmacol Res. 2016. PMID: 27521834 Free PMC article.
Arginine vasopressin receptor 2 activation promotes microvascular permeability in sepsis.
Lopez E, Fukuda S, Modis K, Fujiwara O, Enkhtaivan B, Trujillo-Abarca R, Ihara K, Lima-Lopez F, Perez-Bello D, Szabo C, Prough DS, Enkhbaatar P. Lopez E, et al. Among authors: modis k. Pharmacol Res. 2021 Jan;163:105272. doi: 10.1016/j.phrs.2020.105272. Epub 2020 Nov 4. Pharmacol Res. 2021. PMID: 33160069 Free PMC article.
Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach.
Chao C, Zatarain JR, Ding Y, Coletta C, Mrazek AA, Druzhyna N, Johnson P, Chen H, Hellmich JL, Asimakopoulou A, Yanagi K, Olah G, Szoleczky P, Törö G, Bohanon FJ, Cheema M, Lewis R, Eckelbarger D, Ahmad A, Módis K, Untereiner A, Szczesny B, Papapetropoulos A, Zhou J, Hellmich MR, Szabo C. Chao C, et al. Among authors: modis k. Mol Med. 2016 Sep;22:361-379. doi: 10.2119/molmed.2016.00102. Epub 2016 May 16. Mol Med. 2016. PMID: 27257787 Free PMC article.
Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function.
Suzuki K, Olah G, Modis K, Coletta C, Kulp G, Gerö D, Szoleczky P, Chang T, Zhou Z, Wu L, Wang R, Papapetropoulos A, Szabo C. Suzuki K, et al. Among authors: modis k. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13829-34. doi: 10.1073/pnas.1105121108. Epub 2011 Aug 1. Proc Natl Acad Sci U S A. 2011. PMID: 21808008 Free PMC article.
48 results