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Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro.
Dolan MJ, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, Marsh SE, Goeva A, Lojek NM, Murphy S, White CM, Joung J, Liu B, Limone F, Eggan K, Hacohen N, Bernstein BE, Glass CK, Leinonen V, Blurton-Jones M, Zhang F, Epstein CB, Macosko EZ, Stevens B. Dolan MJ, et al. Among authors: zhang f. Nat Immunol. 2023 Aug;24(8):1382-1390. doi: 10.1038/s41590-023-01558-2. Epub 2023 Jul 27. Nat Immunol. 2023. PMID: 37500887 Free PMC article.
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.
Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F. Joung J, et al. Among authors: zhang f. Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23. Nat Protoc. 2017. PMID: 28333914 Free PMC article.
Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood.
Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F. Joung J, et al. Among authors: zhang f. Nature. 2017 Aug 17;548(7667):343-346. doi: 10.1038/nature23451. Epub 2017 Aug 11. Nature. 2017. PMID: 28792927 Free PMC article.
RNA editing with CRISPR-Cas13.
Cox DBT, Gootenberg JS, Abudayyeh OO, Franklin B, Kellner MJ, Joung J, Zhang F. Cox DBT, et al. Among authors: zhang f. Science. 2017 Nov 24;358(6366):1019-1027. doi: 10.1126/science.aaq0180. Epub 2017 Oct 25. Science. 2017. PMID: 29070703 Free PMC article.
A cytosine deaminase for programmable single-base RNA editing.
Abudayyeh OO, Gootenberg JS, Franklin B, Koob J, Kellner MJ, Ladha A, Joung J, Kirchgatterer P, Cox DBT, Zhang F. Abudayyeh OO, et al. Among authors: zhang f. Science. 2019 Jul 26;365(6451):382-386. doi: 10.1126/science.aax7063. Epub 2019 Jul 11. Science. 2019. PMID: 31296651 Free PMC article.
Disease-associated astrocytes in Alzheimer's disease and aging.
Habib N, McCabe C, Medina S, Varshavsky M, Kitsberg D, Dvir-Szternfeld R, Green G, Dionne D, Nguyen L, Marshall JL, Chen F, Zhang F, Kaplan T, Regev A, Schwartz M. Habib N, et al. Among authors: zhang f. Nat Neurosci. 2020 Jun;23(6):701-706. doi: 10.1038/s41593-020-0624-8. Epub 2020 Apr 27. Nat Neurosci. 2020. PMID: 32341542 Free PMC article.
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