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Novel MECP2 gene therapy is effective in a multicenter study using two mouse models of Rett syndrome and is safe in non-human primates.
Powers S, Likhite S, Gadalla KK, Miranda CJ, Huffenberger AJ, Dennys C, Foust KD, Morales P, Pierson CR, Rinaldi F, Perry S, Bolon B, Wein N, Cobb S, Kaspar BK, Meyer KC. Powers S, et al. Among authors: dennys c. Mol Ther. 2023 Sep 6;31(9):2767-2782. doi: 10.1016/j.ymthe.2023.07.013. Epub 2023 Jul 22. Mol Ther. 2023. PMID: 37481701 Free article.
Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy.
Sinha Ray S, Dutta D, Dennys C, Powers S, Roussel F, Lisowski P, Glažar P, Zhang X, Biswas P, Caporale JR, Rajewsky N, Bickle M, Wein N, Bellen HJ, Likhite S, Marcogliese PC, Meyer KC. Sinha Ray S, et al. Among authors: dennys c. Cell Rep. 2022 Dec 6;41(10):111751. doi: 10.1016/j.celrep.2022.111751. Cell Rep. 2022. PMID: 36476864 Free article.
NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
Baggio C, Kulinich A, Dennys CN, Rodrigo R, Meyer K, Ethell I, Pellecchia M. Baggio C, et al. Among authors: dennys cn. J Med Chem. 2021 Aug 12;64(15):11229-11246. doi: 10.1021/acs.jmedchem.1c00608. Epub 2021 Jul 22. J Med Chem. 2021. PMID: 34293864 Free PMC article.
PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD.
Pilotto F, Schmitz A, Maharjan N, Diab R, Odriozola A, Tripathi P, Yamoah A, Scheidegger O, Oestmann A, Dennys CN, Sinha Ray S, Rodrigo R, Kolb S, Aronica E, Di Santo S, Widmer HR, Charlet-Berguerand N, Selvaraj BT, Chandran S, Meyer K, Zuber B, Goswami A, Weis J, Saxena S. Pilotto F, et al. Among authors: dennys cn. Acta Neuropathol. 2022 Nov;144(5):939-966. doi: 10.1007/s00401-022-02494-5. Epub 2022 Sep 19. Acta Neuropathol. 2022. PMID: 36121477 Free PMC article.
Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation.
Jandy M, Noor A, Nelson P, Dennys CN, Karabinas IM, Pestoni JC, Singh GD, Luc L, Devyldere R, Perdomo N, Mitchell CE, Adams L, Fuse MA, Mendoza FA, Marean-Reardon CL, Mehl RA, Estevez AG, Franco MC. Jandy M, et al. Among authors: dennys cn. Redox Biol. 2022 Apr;50:102247. doi: 10.1016/j.redox.2022.102247. Epub 2022 Jan 26. Redox Biol. 2022. PMID: 35121403 Free PMC article.
Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism.
Franco MC, Ricart KC, Gonzalez AS, Dennys CN, Nelson PA, Janes MS, Mehl RA, Landar A, Estévez AG. Franco MC, et al. Among authors: dennys cn. J Biol Chem. 2015 Jul 31;290(31):19055-66. doi: 10.1074/jbc.M115.663278. Epub 2015 Jun 17. J Biol Chem. 2015. PMID: 26085096 Free PMC article.
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