Sachleben JR - Search Results

1

Thermodynamics and kinetics of DNA and RNA dinucleotide hybridization to gaps and overhangs.

Ashwood B, Jones MS, Radakovic A, Khanna S, Lee Y, Sachleben JR, Szostak JW, Ferguson AL, Tokmakoff A. Ashwood B, et al. Among authors: sachleben jr. Biophys J. 2023 Aug 22;122(16):3323-3339. doi: 10.1016/j.bpj.2023.07.009. Epub 2023 Jul 19. Biophys J. 2023. PMID: 37469144

2

Molecular insight into how the position of an abasic site modifies DNA duplex stability and dynamics.

Ashwood B, Jones MS, Lee Y, Sachleben JR, Ferguson AL, Tokmakoff A. Ashwood B, et al. Among authors: sachleben jr. Biophys J. 2024 Jan 16;123(2):118-133. doi: 10.1016/j.bpj.2023.11.022. Epub 2023 Nov 24. Biophys J. 2024. PMID: 38006207

3

How hydrophobicity, side chains, and salt affect the dimensions of disordered proteins.

Baxa MC, Lin X, Mukinay CD, Chakravarthy S, Sachleben JR, Antilla S, Hartrampf N, Riback JA, Gagnon IA, Pentelute BL, Clark PL, Sosnick TR. Baxa MC, et al. Among authors: sachleben jr. Protein Sci. 2024 May;33(5):e4986. doi: 10.1002/pro.4986. Protein Sci. 2024. PMID: 38607226 Free PMC article.

4

HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker.

Chen R, Glauninger H, Kahan DN, Shangguan J, Sachleben JR, Riback JA, Drummond DA, Sosnick TR. Chen R, et al. Among authors: sachleben jr. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2321606121. doi: 10.1073/pnas.2321606121. Epub 2024 Mar 21. Proc Natl Acad Sci U S A. 2024. PMID: 38513106

5

Molecular insight into how the position of an abasic site and its sequence environment influence DNA duplex stability and dynamics.

Ashwood B, Jones MS, Lee Y, Sachleben JR, Ferguson AL, Tokmakoff A. Ashwood B, et al. Among authors: sachleben jr. bioRxiv [Preprint]. 2023 Jul 25:2023.07.22.550182. doi: 10.1101/2023.07.22.550182. bioRxiv. 2023. PMID: 37546925 Free PMC article. Updated. Preprint.

6

Direct monitoring of the thermodynamics and kinetics of DNA and RNA dinucleotide dehybridization from gaps and overhangs.

Ashwood B, Jones MS, Radakovic A, Khanna S, Lee Y, Sachleben JR, Szostak JW, Ferguson AL, Tokmakoff A. Ashwood B, et al. Among authors: sachleben jr. bioRxiv [Preprint]. 2023 Apr 10:2023.04.10.536266. doi: 10.1101/2023.04.10.536266. bioRxiv. 2023. PMID: 37090657 Free PMC article. Updated. Preprint.

7

Serine 408 phosphorylation is a molecular switch that regulates structure and function of the occludin α-helical bundle.

Srivastava AK, Venkata BS, Sweat YY, Rizzo HR, Jean-François L, Zuo L, Kurgan KW, Moore P, Shashikanth N, Smok I, Sachleben JR, Turner JR, Meredith SC. Srivastava AK, et al. Among authors: sachleben jr. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2204618119. doi: 10.1073/pnas.2204618119. Epub 2022 Aug 15. Proc Natl Acad Sci U S A. 2022. PMID: 35969745 Free PMC article.

8

Prediction and Validation of a Protein's Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence.

Peng X, Baxa M, Faruk N, Sachleben JR, Pintscher S, Gagnon IA, Houliston S, Arrowsmith CH, Freed KF, Rocklin GJ, Sosnick TR. Peng X, et al. Among authors: sachleben jr. J Chem Theory Comput. 2022 Jan 11;18(1):550-561. doi: 10.1021/acs.jctc.1c00960. Epub 2021 Dec 22. J Chem Theory Comput. 2022. PMID: 34936354 Free PMC article.

9

Molecular dynamics study of water channels in natural and synthetic amyloid-β fibrils.

Natesh SR, Hummels AR, Sachleben JR, Sosnick TR, Freed KF, Douglas JF, Meredith SC, Haddadian EJ. Natesh SR, et al. Among authors: sachleben jr. J Chem Phys. 2021 Jun 21;154(23):235102. doi: 10.1063/5.0049250. J Chem Phys. 2021. PMID: 34241272 Free PMC article.

10

Nanodroplet Oligomers (NanDOs) of Aβ40.

Pittman JM, Srivastava AK, Boughter CT, Venkata BS, Zerweck J, Moore PC, Smok I, Tonelli M, Sachleben JR, Meredith SC. Pittman JM, et al. Among authors: sachleben jr. Biochemistry. 2021 Sep 14;60(36):2691-2703. doi: 10.1021/acs.biochem.1c00147. Epub 2021 May 24. Biochemistry. 2021. PMID: 34029056

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