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Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators.
Perkins JJ, McQuade P, Bungard CJ, Diamond TL, Gantert LT, Gotter AL, Hanney B, Hills ID, Hurzy DM, Joshi A, Kern JT, Schlegel KS, Manikowski JJ, Meng Z, O'Brien JA, Roecker AJ, Smith SM, Uslaner JM, Hostetler E, Meissner RS. Perkins JJ, et al. Among authors: schlegel ks. ACS Med Chem Lett. 2023 Jun 13;14(7):986-992. doi: 10.1021/acsmedchemlett.3c00175. eCollection 2023 Jul 13. ACS Med Chem Lett. 2023. PMID: 37465306
Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models.
Shu Y, Diamond TL, Hershey JC, Huang S, Magliaro BC, O'Brien JA, Schlegel KS, Puri V, Uebele VN, Uslaner JM, Wang C, Converso A. Shu Y, et al. Among authors: schlegel ks. Bioorg Med Chem Lett. 2020 May 1;30(9):127066. doi: 10.1016/j.bmcl.2020.127066. Epub 2020 Feb 28. Bioorg Med Chem Lett. 2020. PMID: 32173198
Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc-1 Inhibitors Distinct from Traditional High Throughput Screening.
Kutchukian PS, Warren L, Magliaro BC, Amoss A, Cassaday JA, O'Donnell G, Squadroni B, Zuck P, Pascarella D, Culberson JC, Cooke AJ, Hurzy D, Schlegel KS, Thomson F, Johnson EN, Uebele VN, Hermes JD, Parmentier-Batteur S, Finley M. Kutchukian PS, et al. Among authors: schlegel ks. ACS Chem Biol. 2017 Feb 17;12(2):519-527. doi: 10.1021/acschembio.6b00913. Epub 2017 Jan 6. ACS Chem Biol. 2017. PMID: 28032990 Free article.