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Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
ACS Med Chem Lett. 2023 Jun 2;14(7):949-954. doi: 10.1021/acsmedchemlett.3c00104. eCollection 2023 Jul 13.
ACS Med Chem Lett. 2023.
PMID: 37465299
DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.
Schröder M, Renatus M, Liang X, Meili F, Zoller T, Ferrand S, Gauter F, Li X, Sigoillot F, Gleim S, Stachyra TM, Thomas JR, Begue D, Khoshouei M, Lefeuvre P, Andraos-Rey R, Chung B, Ma R, Pinch B, Hofmann A, Schirle M, Schmiedeberg N, Imbach P, Gorses D, Calkins K, Bauer-Probst B, Maschlej M, Niederst M, Maher R, Henault M, Alford J, Ahrne E, Tordella L, Hollingworth G, Thomä NH, Vulpetti A, Radimerski T, Holzer P, Carbonneau S, Thoma CR.
Schröder M, et al. Among authors: maschlej m.
Nat Commun. 2024 Jan 4;15(1):275. doi: 10.1038/s41467-023-44237-4.
Nat Commun. 2024.
PMID: 38177131
Free PMC article.
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