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591 results

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RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy.
Cuevas-Navarro A, Wagner M, Van R, Swain M, Mo S, Columbus J, Allison MR, Cheng A, Messing S, Turbyville TJ, Simanshu DK, Sale MJ, McCormick F, Stephen AG, Castel P. Cuevas-Navarro A, et al. Among authors: mccormick f. Sci Adv. 2023 Jul 14;9(28):eadf4766. doi: 10.1126/sciadv.adf4766. Epub 2023 Jul 14. Sci Adv. 2023. PMID: 37450595 Free PMC article.
Ras signaling and therapies.
Young A, Lyons J, Miller AL, Phan VT, Alarcón IR, McCormick F. Young A, et al. Among authors: mccormick f. Adv Cancer Res. 2009;102:1-17. doi: 10.1016/S0065-230X(09)02001-6. Adv Cancer Res. 2009. PMID: 19595305 Review.
Dragging ras back in the ring.
Stephen AG, Esposito D, Bagni RK, McCormick F. Stephen AG, et al. Among authors: mccormick f. Cancer Cell. 2014 Mar 17;25(3):272-81. doi: 10.1016/j.ccr.2014.02.017. Cancer Cell. 2014. PMID: 24651010 Free article. Review.
KRAS as a Therapeutic Target.
McCormick F. McCormick F. Clin Cancer Res. 2015 Apr 15;21(8):1797-801. doi: 10.1158/1078-0432.CCR-14-2662. Clin Cancer Res. 2015. PMID: 25878360 Free PMC article. Review.
Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway.
Nan X, Tamgüney TM, Collisson EA, Lin LJ, Pitt C, Galeas J, Lewis S, Gray JW, McCormick F, Chu S. Nan X, et al. Among authors: mccormick f. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):7996-8001. doi: 10.1073/pnas.1509123112. Epub 2015 Jun 16. Proc Natl Acad Sci U S A. 2015. PMID: 26080442 Free PMC article.
Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions.
Gillette WK, Esposito D, Abreu Blanco M, Alexander P, Bindu L, Bittner C, Chertov O, Frank PH, Grose C, Jones JE, Meng Z, Perkins S, Van Q, Ghirlando R, Fivash M, Nissley DV, McCormick F, Holderfield M, Stephen AG. Gillette WK, et al. Among authors: mccormick f. Sci Rep. 2015 Nov 2;5:15916. doi: 10.1038/srep15916. Sci Rep. 2015. PMID: 26522388 Free PMC article.
K-Ras protein as a drug target.
McCormick F. McCormick F. J Mol Med (Berl). 2016 Mar;94(3):253-8. doi: 10.1007/s00109-016-1382-7. Epub 2016 Mar 9. J Mol Med (Berl). 2016. PMID: 26960760 Free PMC article. Review.
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.
Dharmaiah S, Bindu L, Tran TH, Gillette WK, Frank PH, Ghirlando R, Nissley DV, Esposito D, McCormick F, Stephen AG, Simanshu DK. Dharmaiah S, et al. Among authors: mccormick f. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6766-E6775. doi: 10.1073/pnas.1615316113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791178 Free PMC article.
591 results