Humphrys LJ - Search Results

1

Stereochemistry-Driven Interactions of α,γ-Peptide Ligands with the Neuropeptide Y Y₄-Receptor.

Plut E, Calderón JC, Stanojlović V, Gattor AO, Höring C, Humphrys LJ, Konieczny A, Kerres S, Schubert M, Keller M, Cabrele C, Clark T, Reiser O. Plut E, et al. Among authors: humphrys lj. J Med Chem. 2023 Jul 27;66(14):9642-9657. doi: 10.1021/acs.jmedchem.3c00363. Epub 2023 Jul 13. J Med Chem. 2023. PMID: 37440703

2

Dual Piperidine-Based Histamine H₃ and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain.

Szczepańska K, Karcz T, Dichiara M, Mogilski S, Kalinowska-Tłuścik J, Pilarski B, Leniak A, Pietruś W, Podlewska S, Popiołek-Barczyk K, Humphrys LJ, Ruiz-Cantero MC, Reiner-Link D, Leitzbach L, Łażewska D, Pockes S, Górka M, Zmysłowski A, Calmels T, Cobos EJ, Marrazzo A, Stark H, Bojarski AJ, Amata E, Kieć-Kononowicz K. Szczepańska K, et al. Among authors: humphrys lj. J Med Chem. 2023 Jul 27;66(14):9658-9683. doi: 10.1021/acs.jmedchem.3c00430. Epub 2023 Jul 7. J Med Chem. 2023. PMID: 37418295 Free PMC article.

3

[³H]UR-JG102-A Radiolabeled Cyclic Peptide with High Affinity and Excellent Selectivity for the Neuropeptide Y Y₄ Receptor.

Gleixner J, Gattor AO, Humphrys LJ, Brunner T, Keller M. Gleixner J, et al. Among authors: humphrys lj. J Med Chem. 2023 Oct 12;66(19):13788-13808. doi: 10.1021/acs.jmedchem.3c01224. Epub 2023 Sep 29. J Med Chem. 2023. PMID: 37773891

4

A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H₃ Receptor.

Rosier N, Grätz L, Schihada H, Möller J, Işbilir A, Humphrys LJ, Nagl M, Seibel U, Lohse MJ, Pockes S. Rosier N, et al. Among authors: humphrys lj. J Med Chem. 2021 Aug 12;64(15):11695-11708. doi: 10.1021/acs.jmedchem.1c01089. Epub 2021 Jul 26. J Med Chem. 2021. PMID: 34309390

5

Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias.

Schihada H, Klompstra TM, Humphrys LJ, Cervenka I, Dadvar S, Kolb P, Ruas JL, Schulte G. Schihada H, et al. Among authors: humphrys lj. J Biol Chem. 2022 Sep;298(9):102328. doi: 10.1016/j.jbc.2022.102328. Epub 2022 Aug 4. J Biol Chem. 2022. PMID: 35933013 Free PMC article.

6

Lysergic acid diethylamide stimulates cardiac human H₂ histamine and cardiac human 5-HT₄-serotonin receptors.

Gergs U, Jacob H, Braekow P, Hofmann B, Pockes S, Humphrys LJ, Kirchhefer U, Fehse C, Neumann J. Gergs U, et al. Among authors: humphrys lj. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan;397(1):221-236. doi: 10.1007/s00210-023-02591-6. Epub 2023 Jul 4. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37401967 Free PMC article.

7

Clonidine stimulates force of contraction via histamine H₂ receptors in the human atrium.

Neumann J, Pockes S, Humphrys LJ, Mönnich D, Forster L, Kirchhefer U, Hofmann B, Gergs U. Neumann J, et al. Among authors: humphrys lj. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan;397(1):617-626. doi: 10.1007/s00210-023-02635-x. Epub 2023 Jul 25. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37490122 Free PMC article.

8

Ergometrine stimulates histamine H₂ receptors in the isolated human atrium.

Jacob H, Braekow P, Hofmann B, Kirchhefer U, Forster L, Mönnich D, Humphrys LJ, Pockes S, Neumann J, Gergs U. Jacob H, et al. Among authors: humphrys lj. Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec;396(12):3809-3822. doi: 10.1007/s00210-023-02573-8. Epub 2023 Jun 24. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 37354215 Free PMC article.

9

Illuminating Neuropeptide Y Y₄ Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools.

Gleixner J, Kopanchuk S, Grätz L, Tahk MJ, Laasfeld T, Veikšina S, Höring C, Gattor AO, Humphrys LJ, Müller C, Archipowa N, Köckenberger J, Heinrich MR, Kutta RJ, Rinken A, Keller M. Gleixner J, et al. Among authors: humphrys lj. ACS Pharmacol Transl Sci. 2024 Mar 20;7(4):1142-1168. doi: 10.1021/acsptsci.4c00013. eCollection 2024 Apr 12. ACS Pharmacol Transl Sci. 2024. PMID: 38633582

10

Activation of Multiple G Protein Pathways to Characterize the Five Dopamine Receptor Subtypes Using Bioluminescence Technology.

Mönnich D, Humphrys LJ, Höring C, Hoare BL, Forster L, Pockes S. Mönnich D, et al. Among authors: humphrys lj. ACS Pharmacol Transl Sci. 2024 Feb 6;7(3):834-854. doi: 10.1021/acsptsci.3c00339. eCollection 2024 Mar 8. ACS Pharmacol Transl Sci. 2024. PMID: 38481695

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