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A Phase Ib Trial of AVID200, a TGFβ 1/3 Trap, in Patients with Myelofibrosis.
Mascarenhas J, Migliaccio AR, Kosiorek H, Bhave R, Palmer J, Kuykendall A, Mesa R, Rampal RK, Gerds AT, Yacoub A, Pettit K, Talpaz M, Komrokji R, Kremyanskaya M, Gonzalez A, Fabris F, Johnson K, Dougherty M, McGovern E, Arango Ossa J, Domenico D, Farnoud N, Weinberg RS, Kong A, Najfeld V, Vannucchi AM, Arciprete F, Zingariello M, Falchi M, Salama ME, Mead-Harvey C, Dueck A, Varricchio L, Hoffman R. Mascarenhas J, et al. Among authors: zingariello m. Clin Cancer Res. 2023 Sep 15;29(18):3622-3632. doi: 10.1158/1078-0432.CCR-23-0276. Clin Cancer Res. 2023. PMID: 37439808 Free PMC article. Clinical Trial.
TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis.
Varricchio L, Iancu-Rubin C, Upadhyaya B, Zingariello M, Martelli F, Verachi P, Clementelli C, Denis JF, Rahman AH, Tremblay G, Mascarenhas J, Mesa RA, O'Connor-McCourt M, Migliaccio AR, Hoffman R. Varricchio L, et al. Among authors: zingariello m. JCI Insight. 2021 Sep 22;6(18):e145651. doi: 10.1172/jci.insight.145651. JCI Insight. 2021. PMID: 34383713 Free PMC article.
Preclinical studies on the use of a P-selectin-blocking monoclonal antibody to halt progression of myelofibrosis in the Gata1low mouse model.
Verachi P, Gobbo F, Martelli F, Falchi M, di Virgilio A, Sarli G, Wilke C, Bruederle A, Prahallad A, Arciprete F, Zingariello M, Migliaccio AR. Verachi P, et al. Among authors: zingariello m. Exp Hematol. 2023 Jan;117:43-61. doi: 10.1016/j.exphem.2022.09.004. Epub 2022 Oct 1. Exp Hematol. 2023. PMID: 36191885 Free PMC article.
Increased differentiation of dermal mast cells in mice lacking the Mpl gene.
Ghinassi B, Zingariello M, Martelli F, Lorenzini R, Vannucchi AM, Rana RA, Nishikawa M, Migliaccio G, Mascarenhas J, Migliaccio AR. Ghinassi B, et al. Among authors: zingariello m. Stem Cells Dev. 2009 Sep;18(7):1081-92. doi: 10.1089/scd.2008.0323. Stem Cells Dev. 2009. PMID: 19025339 Free PMC article.
45 results